Discover and read the best of Twitter Threads about #complement

Most recents (6)

How is immunity to SARS-CoV-2 induced and subsequently controlled?

A new study has uncovered an important role for #complement in the induction of innate and adaptive immunity to SARS-CoV-2. 1/
Complement rapidly opsonized SARS-CoV-2 via lectin pathway. Complement-opsonized SARS2 efficiently interacted w/ dendritic cells (DCs), inducing Type I IFN & pro-inflammatory cytokine responses, which were inhibited by antibodies against complement receptors (CR)3 and CR4. 2/ ImageImage
These findings suggest that complement is important in inducing immunity via DCs in the acute phase against SARS-CoV-2. 3/
Read 6 tweets
[#BreakingNews] L'#eolien et le #solaire en 2021/22, ce sont 14,4 Mds€ de revenus en plus pour l'Etat ! Une nouvelle ressource bienvenue pour financer la limitation des prix de l’électricité à 4% et protéger le #pouvoirdachat des 🇫🇷.
On vous explique 🧵 #Thread (1/7) 👇
Une taxe existe pour soutenir les #EnR en fonction des prix du marché ➡️ #CSPE. Avec la crise de l'#énergie les prix ne cessent de grimper. Les taxes sont en même temps revues à la baisse par @CRE_energie. Pourquoi à la baisse ? Parce que les #EnR auj. rapportent à l'Etat (2/7)
En France il existe un mécanisme #GagnantGagnant pour l'#éolien et l'Etat : le complément de rémunération. Il permet un soutien public vers les #EnR en 🇫🇷 et fixe un prix cible lors des appels d'offres. Voici comment cela fonctionne ⬇️ (3/7)
Read 7 tweets
Join us tomorrow for the launch of a new accredited tweetorial – a case-based program on the assessment and management of patients with IgA #nephropathy (#IgAN). Free CE/#CME for #physicians, #nurses, #pharmacists! Expert author none other than @IgAN_JBarratt. FOLLOW US . . .
. . . and tell your colleagues to join you here on @ckd_ce, your ONLY source for accredited #tweetorials in the #CKD space! #nephtwitter #nephjc @nephondemand @Nephro_Sparks @edgarvlermamd @ChristosArgyrop @goKDIGO @nicklimd @CKJsocial @ERAkidney @kidney_boy @kidneypathology
1) Welcome to our accredited #tweetorial on optimal contemporary mgt of #IgAN. Earn 0.5h CME/CE credit #physicians #nurses #nursepractitioners #physicianassistants by following this thread. I am @IgAN_JBarratt. @MedTweetorials #nephtwitter #nephjc #FOAMed #MedEd Image
Read 56 tweets
A compilation on current data on seasonality of SARS-CoV-2 as well as historic data on other virus, such as common cold HCoV's and influenza

➡️ Temperature
➡️ Humidity
➡️ UVB
➡️ Vitamin D
➡️ Indoor vs outdoor
➡️ Dose exposure
➡️ Ventilation

1/x
Leading virus immunity expert Iwasaki on seasonality of virus: highlights the importance of the environmental factors: temperature, humidity as well as vitamin D status, in modulating immune responses to viral infections in the respiratory tract annualreviews.org/doi/10.1146/an…
2/x
Temperature, Humidity, and Latitude Analysis to Estimate Potential Spread and Seasonality of Coronavirus Disease 2019 (COVID-19).
3/x
jamanetwork.com/journals/jaman…
Read 40 tweets
1/ A continuation #tweetorial from my last one introducing human leukocyte antigen (#HLA) , the cell surface antigen...

Below, let's briefly review basics of #Luminex testing & "cross-matching."

What/who is Luminex?
2/ In this #tweetorial, we'll answer 3Qs that help us assess a #kidneytransplant recipient's immunological risk:

1. Does this recipient have #DSA* (against HLA-antigens) ?
2. Can the antibodies bind?
3. Can the antibodies activate complement?

*DSA: donor specific antibodies
3/ Q1: How do know if the recipient's serum contains DSA against HLA-antigens?

A1: #Luminex testing, a solid-phase (BEAD) based assay. To perform the test, take the recipient's serum and pipette it into multiple wells - each well has beads coated with #HLA antigens...
Read 12 tweets
National DNA Day:

🧬April 25

🧬Commemorates the day in 1953 when Watson, Crick, Wilkins, Franklin and colleagues published papers in the journal @nature on the structure of DNA

🧬Also commemorates the completion of the Human Genome Project in April 2003, took 13 years

#DNADay
DNA Double Helix:

🧬The two #DNA strands are reverse-complements

🧬Reading one strand in #reverse order and exchanging each base with its #complement gives the other strand

🧬A and T are complements, C and G are complements

DNA Sequence: AGTAGCAT
Reverse-Complement: ATGCTACT
In #Each DNA Strand:

🧬Pull the #DNA double helix apart, leaving the two single DNA strands

🧬The population (or occurrence) of every DNA sequence in that single-strand is #equivalent to the population of its reverse-complement DNA sequence in that same single-strand

#Genomics
Read 5 tweets

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