Discover and read the best of Twitter Threads about #cyclobenzaprine

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THREAD: Bring it down safely! ↘️💊

1/6 6⃣tweets about our new TI Therapeutics Letter 134: Finding the lowest effective dose for non-opioid #analgesics

👉🏾 Full Letter: ti.ubc.ca/letter134

#MedEd #medsafety #prescribing #BetterPrescribing Image
2/6 Consistent evidence that minority of pts get clinically meaningful pain relief from any dose of:
#Cyclobenzaprine (at best 1/4)
#Duloxetine (at best 1/6)
#Gabapentin / #Pregabalin (at best 1/6)

👉🏾ti.ubc.ca/letter134

#MedEd #ptsafety #BetterPrescribing #prescribing Image
3/6 Gabapentin, pregabalin, duloxetine:

A 2021 Canadian systematic review found NNT (numbers needed to treat) of 6-7 for "clinically meaningful benefit" (defined as ≥30% reduction in pain or pain & function)

👉🏾ti.ubc.ca/letter134

#MedEd #BetterPrescribing #deprescribing Image
Read 7 tweets
A #special #warning for my folks w or w/o #disabilities who might be taking #Flexeril / #cyclobenzaprine

it says on the warning sheet that very few folks have had #depressive #sideeffects, and maybe I'm just a rarity.

but if i have to take that thing for 2x in a row
waaaugh!
It's small & #insidious.
It starts with "will I ever get better?" & it can escalate into, "Why do I try?" depending how long I am on it.

I only need it sporadically, but yeah.
Changed my world to know that was a possibility.
Now I can say after using it..."Is this thought real?"
For those who would suggest other methods, this one is the best one i have for now.
(In a few years, maybe something that works better will come along or they might know more about why #EhlersDanlos happens)

In the mean time I wanted you to know, in case this happens to you too.
Read 3 tweets

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