Discover and read the best of Twitter Threads about #nerves

Most recents (9)

SEMINAL ARTICLE re: #ICD11 Chapter 08 - Diseases of the #NervousSystem 🧠

Study Title: The #leptomeninges as a critical organ for normal #CNS development and function: first patient and public involved systematic review of #arachnoiditis (chronic #meningitis). @PLOSONE
LINK: journals.plos.org/plosone/articl… @PLOSONE

Abbreviations:
#CES- #CaudaEquina Syndrome
#DLM – Diseases of the #Leptomeninges
#ESI- #Epidural Steroid Injection
LM - #Leptomeninges
#LMF- #Leptomeningeal #Fibrosis
#NAA- #neuraxialanesthesia
PSR- PRISMA Systematic Review
#SAH- #Subarachnoid Hemorrhage
#SAS- #Subarachnoid Space

Key Findings:

1. A varyingly described, and poorly characterized #CNS disease called #arachnoiditis (aka #adhesivearachnoiditis) was exhaustively systematically-reviewed for the first time.
Read 27 tweets
@kimisgubbed @VirusesImmunity @KaminskiMed @Be_Kinderr @jenbrea @ahandvanish Hey! Well hypoxic tissue cld lead to lower O2 extraction, & infected tissue is often hypoxic. Most intracellular pathogens hijack metabolism of cells they infect & “push” host mitochondrial metabolism to anerobic glycolysis (O2 not being used for OXPHOS): ij.hapres.com/htmls/IJ_1341_…
@kimisgubbed @VirusesImmunity @KaminskiMed @Be_Kinderr @jenbrea @ahandvanish 2/ In fact many intracellular #pathogens either directly or indirectly enhance hypoxia inducible factor (HIF-1) stability. HIF-1 is a key glycolytic regulator/transcription factor whose stability reduces reliance on OXPHOS by initiating glycolytic #metabolism
@kimisgubbed @VirusesImmunity @KaminskiMed @Be_Kinderr @jenbrea @ahandvanish 3/ With that in mind @VirusesImmunity, it was interesting that in your brain organoid model, you showed SARS-CoV-2 capable of infecting neurons, where it induced a locally hypoxic environment as measured by staining for HIF-1 alpha: pubmed.ncbi.nlm.nih.gov/33433624/
Read 11 tweets
As soon as we finish in Theatre we have planned a little jaunt to see an actual live volcanic eruption. Nothing out of the ordinary to see here! 🇮🇸 🇬🇧 #nerves&volcanoes
Off to see the 🌋 🎉. 😀🤩
So… I want to tell you about my experience of seeing a real volcano. It feels a bit indulgent to go on but I can’t fit this into one tweet- Today I saw a volcano. …
Read 15 tweets
Thanks @DrDavidACox for interviewing me for this article on #LongCovid. There’s also great info in the article on research showing #viral RNA in the brains of patients w/ post-SARS syndrome, and viral reservoirs in patients w/ post-Ebola Syndrome: bbc.com/future/article…
2/ The article reads: “Amy Proal, a microbiologist who runs the @polybioRF which studies the causes of chronic inflammatory diseases, believes that small amounts of #pathogens that linger beyond the reach of the immune system in remote pockets of the body...
3/ “...known as reservoirs or anatomical sanctuaries, are at least partially responsible for a whole range of post-infectious syndromes. This includes long #Covid, but also a number of mysterious illnesses which have puzzled scientists for decades, such as chronic Lyme disease..
Read 14 tweets
Open water swimmers and winter people all, do you wonder how you feel cold? Well it’s the wonder of nerves again - let me tell you some nerve nerdy stuff... #openwaterswimming #thestoics #sensorynerve #cold
A thread :
Cool is a pleasurable feeling and warm too but hot and cold break into painful feelings. This appreciation of temperature is a protective function of nerves but how does it all work? How does your body tell your brain about the word outside?
If we step into a lake or river in winter the free nerve endings in the skin can tell us what temperature the water is. This is possible between -10 and 60°C in mammals. How this works is a very clever story and is linked with 🌶 and mints! Keep reading.. 🧊
Read 16 tweets
4 THINGS YOU SHOULD KNOW ABOUT #TETANUS

1. Enters your body through wounds
2. Makes muscle contract painfully
3. Can kill in days if no treatment
4. No cure, so better to PROTECT YOURSELF!

A thread 🧵

{Share for awareness!}
Tetanus is caused by a germ called Clostridium tetani.

This germ produces a dangerous #toxin that makes your muscles painfully contract on their own & become rigid.

This man had neck stiffness & lockjaw from tetanus;
Tetanus germ lives mainly inside the soil & animal feces. It lives there for years.

When it has a chance, it enter your body through:
- Wounds contaminated with soil or feces, or
- Punctures by nonsterile needles (like some injecting illegal drugs, tattooing or body piercing)
Read 15 tweets
1\. THIS CHILD & THIS MAN DIED OF #TETANUS!

It is a terrible disease that enters your body through #wounds & can kill in days if nothing is done fast!

{SHARE to create awareness!} ImageImage
2\. #Tetanus results from a #toxin produced by the bacteria called Clostridium tetani.

This toxin makes your muscles to contract on their own (i.e. involuntarily), becoming rigid like this; Image
3\. Tetanus lives in soil & animal feces. It can live there for years. It may then enter your body through:

-#Wounds contaminated with soil or feces

-Skin #punctures by nonsterile needles (e.g. when injecting illegal drugs, #tattoo or body piercing)
Read 12 tweets
Incredibly important hypothesis piece published today 👉 “Proposed here is a theory that #microorganisms from within the #brain and elsewhere in the body contribute to the long-term #neurological deterioration characteristic of traumatic brain injury”: sciencedirect.com/science/articl…
From paper 👉 1. “First, since the normal human #brain is not sterile, but is host to a variety of microorganisms, blows to the #skull may dislodge them from their accustomed local environments, in which they have been living in quiet equilibrium with neighboring #brain cells”
2. “2nd, upon impact commensal #microbes already resident on surfaces of the nose, mouth + eyes, and potentially harmful organisms from the environment, may gain access to the #brain through the distal ends of the olfactory + optic #nerves or even a disrupted blood-brain barrier”
Read 6 tweets
Some of my #takeaways & #notes from various #DECMA sessions this weekend. (1/n)
By @madan_kumar
- Build a rock solid trading plan
- Treat trading like a business
- Limit your time spent with the trading business
- Take the extra time that trading allows you to have and spend it with your family
(2/n)
By @Raminations
- Use all experiences positive and negative for building future plans
- Understand the products you are trading to the smallest details
- If a position or trade is giving you sleepless nights, get out of it immediately the next morning.
(3/n)
Read 19 tweets

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