Discover and read the best of Twitter Threads about #outcomes

A journey which started in 2016 has led to the publication of the #PREPARE study in @TheLancet today. In this #randomised study, we show that a 12-gene panel can reduce #adverse_effects by 30%. authors.elsevier.com/c/1gX95V-4XHGbk @CDSS_Liverpool @pandtuol

A 30% reduction in adverse reactions from a single #intervention is remarkable. news.liverpool.ac.uk/2023/02/03/mat… #pharmacogenetics #personalisedmedicine #adverse_effects. The study was funded by the Horizon 2020 program by the @eu_comission

Led by @HenkJGuchelaar and @JesseSwen as part of the #UPGx consortium: upgx.eu. All #ADRs were assessed for #causality by the Liverpool Causality Assessment Tool (LCAT): journals.plos.org/plosone/articl…

Read 7 tweets

TaNaisha NOT MILD Lee

@TaNaishaJ

1/4 "... findings suggest #organizational #priorities can potentially #disturb #natural #patterns of #gestation and #birth #timing..."

journals.plos.org/plosone/articl…

2/4 "... with a potential to improve U.S. #perinatal #outcomes with organizational models that more closely resemble those of #England and the #Netherlands."

3/4 "In the U.S., however, a decidedly different pattern emerged. #Vaginal #births without #induction or #augmentation in U.S. hospitals were far more likely to occur during #standard #working #hours."

#infant #neonates #prenatal #perinatal #health #outcomes #maternal

Read 4 tweets

Umbereen S. Nehal, MD, MPH

@usnehal

#antivaxx efforts now even use #deepfake

to target #refugee, Black, religious minority communities

like measles outbreak in Minnesota in 2019: Wakefield was flown in TO spread #misinformation & #disinformation

Now: online fake accounts/fake identities vs #VaccinesWork

https://twitter.com/oni_blackstock/status/1471228788323328004

What has #healthcare been doing meanwhile?

#Medbikini: Teach (male Asian) med students to make fake accounts to cyberstalk trainees’ personal Facebook for: bikini
or “being political” or “religious” (#BLM)

➡️“model minority” pipeline for “shadow faculty” vs Blck @ayshakhoury

#Medbikini #research got flak for men vs women

BUT was ALSO fake acct #surveillance vs #BLM like drove out @ayshakhoury @uche_blackstock @nhannahjones

While academia has ignored #vaccineequity
➡️ongoing #pandemic & deaths in marginalized targeted by #antivaxx

@womanistpsych

https://twitter.com/uche_blackstock/status/1350450305209692160

Read 23 tweets

WorldStrokeAcademy

@WorldStrokeEd

#WeekendLecture
#CerebralMicrobleeds #CMB

Radiological construct: small (2–10 mm diameter) round or ovoid #hypointense foci with associated #blooming with enhanced visibility on #MRI sequences sensitive to #susceptibility effects

thelancet.com/journals/laneu…

#WeekendLecture
#CMB
🔬#Pathology: recent or old microhaemorrhages
🩸Microvessel injuries, ie: dilatation/fragmentation of the wall, amyloid-ß (in CAA) and fibrin extravasation
🩸Extravasation of red blood cells
🩸#hemosiderin-laden macrophages
karger.com/Article/FullTe…

#WeekendLecture

In daily practice #CMB represents a radiological marker of #small vessel disease

In general:
🩸Strictly #lobar CMBs👉CAA
🩸Strictly #deep👉hypertension-related SVD ie #arteriolosclerosis
🩸Mixed 👉combination👆, but must think #hereditary #SVD, ie #CADASIL

Read 8 tweets

COVIDSurg

@CovidSurg

We proudly share the first @CovidSurg @GlobalSurg paper published in @Anaes_Journal based on the world’s biggest data about surgery following SARS-CoV-2 infection. Hopefully, it will guide practice.

📃It is open access and you can read it here 👇 doi.org/10.1111/anae.1…

@CovidSurg @GlobalSurg Week was an international, prospective cohort study with more than 140,000 surgical patients from 116 countries enrolled 🌏🌎🌍

We compared 30-day postoperative mortality in previously infected patients with SARS-CoV-2 vs patients who never were infected

Previously infected patients having surgery at 0-2, 3-4, 5-6 weeks after the infection have higher mortality rates than patients who never got infected with SARS-CoV-2

Read 6 tweets

Umbereen S. Nehal, MD, MPH

@usnehal

This. Black nurses like @mclemoremr who not only have authentic clinical and community experience, not only know the disparities data, but also are winning grants to do the studies themselves belong on the transition committee or COVID Task Force.

https://twitter.com/coryellen/status/1327020047894597632

In contrast when I have taught medical students straight from @AmerAcadPeds policy statements on racism in a hospital with a disparities center, have been told by a division chief that nurses find me “too political” which exactly is this that @COCoQC lays out

Not safe spaces

Repeatedly I “break ranks” - I don’t spend my time on outrage over “scope creep” - who is serving in the communities where Black women die at a 12x higher rate from maternal mortality? Not the doctors or nurses battling on own job & pay.
Is these ppl: mededportal.org/doi/full/10.15…

Read 28 tweets

Society of Interventional Radiology

@SIRspecialists

Kicking off multidisciplinary Research Consensus Panel (RCP) to finally investigate the ❓: what is the optimal medical therapy (OMT) following venous recan? Follow #VenousRCP throughout the day to learn more and contribute! #SIRFoundation @SIRRFS @SIR_ECS @JVIRmedia

🔴 Pathophysiology of venous thromboembolism #VTE
🟠Venous recanalization & stenting
🟡The mystery of medical therapy following recanalization
🟢Patency & outcome measures
🔵Economics & cost-effectiveness of treatment
🟣Future directions
#VenousRCP

🔴 ✅#VTE affects ~100 of every 100,000 people yearly in the US
✅Incidence of VTE ⬆️⬆️ exponentially with age, especially after 40
✅#Endovascular recan is a common tx; post-tx algorithms vary widely
✅More #epidemiology info @CircAHA bit.ly/37IptZh
@Pertconsortium

Read 24 tweets

Philipp Golka

@PGolka

1/ With financial innovations such as #sustainablefinance and #impactinvesting increasingly viewed as key to the solution of current social and environmental crises, let’s take a look at how we got here, what might be problematic about that and what to do about it. 👇

2/ This is a thread about the empirical part of my book that traces the history of #socinv in the UK. I’ll leave the theoretical argument based on Fligstein & McAdam’s strategic action field theory & pragmatist action theory for another time.
springer.com/gp/book/978303…

3/ Financial innovations such as #impinv or #socinv mean that firms succeed to make money from financial intermediation where they haven’t done before. To do so, these firms have to make others participate: investees wanting finance, gov to regulate (and often subsidize), etc.

Read 16 tweets

Nicola Low #StopCovid19 #StillFBPE

@nicolamlow

The #COVID19 data problem in Switzerland. As ⁦@sbonhoeffer⁩ says, we need to analyse #ContactTracing data to look at where coronavirus is, but they still aren’t available... 1/n

derbund.ch/clubs-oder-fam…

The point is to have info to break transmission chains. Showing that families account for a large proportion of #COVID19 is one thing. But it doesn’t show the source of infection. Where did the family member get infected? #ContactTracing should joint the dots... 2/n

No identifiable #COVID19 source outside the family is a warning ⚠️ That means #CommunityTransmission not controlled. And that means we need to #TestTestTest to find infections, then #TestTraceIsolateQuarantine to stop transmission ...3/n

Read 5 tweets

Phil Booth

@EinsteinsAttic

Classic error of thinking. Just because something has (sort of) been made to work in emergency circumstances does not make it 'better', or even as good!

We may now have some evidence to #compare the experience & #outcomes of online consultations, but...
theguardian.com/society/2020/j…

...@MattHancock is being ridiculously precipitant in even suggesting online consultations should be the 'default'.

His (pre-existing) agendas are showing, and until he & his Department show themselves capable of ensuring necessary care - and consistent #evidence of it! - he'd...

...be better off staying well away from trying to define clinical practice.

(Similar goes for those thinking public attitudes towards what's done with their data have significantly changed; indeed, failures of #transparency in the pandemic may end up further eroding #trust.)

Read 4 tweets