Discover and read the best of Twitter Threads about #ClinicalTrialsDay
Most recents (3)
Throughout #ClinicalTrialsDay, we shall share infographics highlighting a key point from each presentation from our Clinical Trials at the Speed of COVID-19 event (a 🧵).
1/ Dr. @PeterASinger introduced our event, emphasizing the importance of clinical trials in innovation.
1/ Dr. @PeterASinger introduced our event, emphasizing the importance of clinical trials in innovation.
2/ Dr. Cecilia Costiniuk discussed the challenges faced when conducting the ongoing nationwide COVAXHIV (@CIHR_CTN), including the need for research protocol flexibility during times of uncertainty.
3/ Dr. Natasha Press highlighted the importance of preparing physicians with supportive infrastructure to guide and support their participation in clinical trials.
On international #clinicaltrialsday, it's worth* trial advocates (of which I'm one) taking a step back and acknowledging some of the limitations of the RCT.
* I think it's worth it and I've got a pre-print to publicise.
Here goes...(1/20)
* I think it's worth it and I've got a pre-print to publicise.
Here goes...(1/20)
Our paper asked: do RCT participants match their intended target population, and does it matter if they don't?
Short answers - probably not, and MAYBE not. There's many arguments and counter-arguments on this. I won't get them all in. (2/20)
jclinepi.com/article/S0895-…
Short answers - probably not, and MAYBE not. There's many arguments and counter-arguments on this. I won't get them all in. (2/20)
jclinepi.com/article/S0895-…
Firstly, there's plenty of literature saying RCT participants are different to non-participants. Below is a convenience sample of *reviews* which show this. Some of these findings may spurious (multiple comparisons etc), but... at face value, it's a bit concerning. (3/20)
Há 273 anos, em 20/05 de 1747, o mundo conhecia o primeiro ensaio clĂnico randomizado (ou “trial”), o tipo de estudo capaz de evitar a maior quantidade de vieses de coincidĂŞncia.
Mas a história começou bem antes disso, na Babilônia... 🧵
Mas a história começou bem antes disso, na Babilônia... 🧵
Está descrito na BĂblia (livro de Daniel) que Nabucodonosor, rei da BabilĂ´nia, fez o primeiro ensaio da histĂłria. Dividiu pessoas para fazerem dieta com carnes e vinhos versus legumes e água.
Após 10 dias, estes últimos “pareciam mais saudáveis”.
Após 10 dias, estes últimos “pareciam mais saudáveis”.
Em 1747 que James Lind fez o que Ă© considerado o primeiro ensaio clĂnico: dividiu marinheiros em seis grupos e dois desses pacientes se alimentaram de frutas cĂtricas, sendo curados e atĂ© ajudaram nos cuidados dos outros. Era descoberta a cura para o Escorbuto.
