Discover and read the best of Twitter Threads about #Interferons

Most recents (5)

#location location location: thrilled to share our work @CellCellPress! #interferons dictate #COVID19 severity! Specific #IFNs are produced along the #airways in response to #SARSCoV2 and drive protective or detrimental #transcriptional programs! 1/7 doi.org/10.1016/j.cell…
IFNs are driven by high #viral #loads, suggesting that viral recognition is only achieved when #SARSCoV2 reaches a certain threshold! Efficient induction of protective IFNs is preferentially achieved by younger patients, further explaining susceptibility of elders to #COVID19 2/7
#IFNL1 & #IFNL3 characterize mild illness & drive potent anti-#SARSCoV2 #ISGs in the upper #airways. Severe patients show #typeI IFN & #IFNL2 along the respiratory tract but lack ISGs, dampen cell proliferation programs associated to #repair and boost #apoptotic #p53 pathways 3/7
Read 7 tweets
Can a respiratory #virus infection confer #immunity against the other #respiratory virus? A much-debated issue in the virus immunology for many decades. What is the probable immune mechanism & does it indeed exist? What is the evidence for & against this hypothesis? 1/
It is hypothesized that a respiratory virus infection confers immunity against the same and other respiratory viruses for a short time, perhaps a few weeks. This immunologic mechanism, known as #heterosubtypic ‘temporary non-specific immunity’ 2/
This immune protection is associated with activation of the innate immune response to viral infection mediated by the release of Type I #interferons (IFN) & other cytokines that have broad protective effects against a range of viruses 3/
Read 21 tweets
How does the immune system work? Will there be #COVID19 vaccines? @BioRender & I put together ‘immunology 101 tweetorial for non-immunologists’. @jerryguartist, @shizaoki, @JungHeeSciViz also made this accompanying video. Please share widely! (1/n)

The immune system protects the host from invading pathogens through 2 layers: the innate and adaptive immunity. Innate immunity acts within minutes to remove the pathogen. Adaptive immunity takes days/wks but is specific & long lived, and is the basis for #vaccines. (2/n)
Innate immunity starts by triggering sensors that detect unusual molecules or activities, known as pattern recognition. Once microbial patterns are detected by these sensors (#PRR), they trigger immediate alarm through secretion of #cytokines and #interferons. (3/n)
Read 13 tweets
An amazing collaborative effort (🇺🇸🇨🇦🇩🇪) where we reveal a new isoform of #ACE2 which we called dACE2! Importantly the shorter, inactive form dACE2, not ACE2, is the form induced by #Interferons and viruses!
biorxiv.org/content/10.110… 1/3
I remember running that first qPCR to test a hypothesis @prokuninaolsson had, but couldnt test right away since her lab was shut. After a lot of hard work by her group and the whole team, and great zoom meetings, we have learned a lot but still more to understand! 2/3
dACE2 is NOT found in non-primates and therefore helps explain why Ace2 was not an ISG in mouse experiments. It also means IFN #COVID19 therapies should not promote the full length ACE2 receptor used by #SARSCoV2 ! 3/3
Read 3 tweets

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