Discover and read the best of Twitter Threads about #Vasculitis22

Most recents (24)

Parallel Session V: Outcomes

Cardiovascular Burden in Patients With ANCA-Associated and Non-ANCA Associated Vasculitis

Dr. Ana B Arevalo

@ANABELENAREVAL2

#Vasculitis22
Retrospective cohort study

AAV and non ANCA associated vasculitis compared

CV outcomes of interest.

#Vasculitis22 ImageImageImage
AAV higher risk of mortality even when adjusted for potential confounders.

#Vasculitis22 Image
Read 4 tweets
Parallel Session V: Outcomes

Outcomes in ANCA-Associated Vasculitis: Validating a Renal Risk Score and Examining the Impact of Deprivation

Dr. Dominic McGovern

@DomP_McGovern

#Vasculitis22
Large national cohort in Scotland

All renal biopsies in Scotland from 2014-2020 included.

EGPA and double positivity excluded.

#Vasculitis22 Image
Renal risk score was good at differentiating ESKD outcomes and prediction of relapse.

#Vasculitis22 ImageImage
Read 5 tweets
Parallel Session V: Outcomes

Malignancies in Patients with AAV Treated Within the EUVAS Trials

Dr. Beatriz Sánchez Álamo

#Vasculitis22
Future cancer risk is a concern with immunosuppression for AAV.

ncbi.nlm.nih.gov/pmc/articles/P…

#Vasculitis22
Aims of this were to analyse results from extended follow up of patients who participated in EUVAS prospective RCTs.

#Vasculitis22 ImageImage
Read 7 tweets
Parallel Session V: Outcomes

Neurologic Involvement in Anca-Associated Vasculitis: Data From Multicenter Longitudinal Observational Study

Prof. Rula Hajj-Ali

@RulaHajjAliMD

#Vasculitis22
Neurological involvement is common in AAV but has a variable presentation and not well studied.

#Vasculitis22 ImageImage
Aims and methods

#Vasculitis22 ImageImage
Read 6 tweets
Parallel Session IV: Paediatric Vasculitis
Monogenic Mimics of Behçet’s Disease

Dr Alice Burleigh

@burleigh_alice

#Vasculitis22
More Monogenic Mimics of Behçet’s Disease have been reported recently but not thoroughly investigated

Aim and 1-slide method

#Vasculitis22
Going on to the findings

#Vasculitis22
Read 4 tweets
Parallel Session IV: Paediatric Vasculitis

Characteristics of Pediatric ANCA Associated Vasculitis Among Racial/Ethnic Minorities- single center experience from United States

Dr Deepika Singh
#Vasculitis22
The aim of this study was to study the characteristics of pediatric patients from racial/ethnic minorities with AAV

1-slide methods

#Vasculitis22
Going on to the results

#Vasculitis22
Read 4 tweets
Parallel Session IV: Paediatric Vasculitis

Differentiating MIS-C from Kawasaki Disease, the second most common vasculitis of childhood

Prof. Seza Ozen

#Vasculitis22
Both have similar clinical manifestation and laboratory findings

This study aims to identify features to differentiate between the 2 diseases

Pictures of diagnostic criteria of both diseases

#Vasculitis22
1-slide methods

#Vasculitis22
Read 5 tweets
Parallel Session IV: Paediatric Vasculitis

Outcomes of kidney transplantation in childhood-onset ANCA-associated vasculitis. A multicentre study

Dr Giorgio Trivioli

#Vasculitis22

1/6
Aim:
describe kidney transplantation outcomes among childhood-onset AAV

Inclusion criteria:
Diagnosis <18 yrs
Kidney transplant with at least 6 mo. follow-up

Exclusion criteria:
Kidney failure not due to AAV
Multi-organ transplant

21 centers
55 patients

#Vasculitis22
Baseline features, n=55:
Female 42 (76%)
Median age of diagnosis: 12
Deceased donor recipient: 35 (64%)
ANCA positivity at transplant: 14 (26%)

#Vasculitis22
Read 6 tweets
Parallel Session III: Proteomics and Metabolomics

Context and Future

Dr. Andreas Kronbichler

@AKronbichler
How can we use biomarkers in vasculitis?

pubmed.ncbi.nlm.nih.gov/24257367/

#Vasculitis22 Image
Read 4 tweets
Parallel Session III: Proteomics and Metabolomics

Deconvolution of Transcriptomic Data Reveals Immune Cell Landscape of Inflammatory Infiltrates in Giant Cell Arteritis

Mr. Michal Zulcinski

#Vasculitis22
There are different patterns of inflammation in GCA.

#Vasculitis22
Aim to use transcriptomic data from GCA positive patients to elucidate GCA pathogenesis and identify new pathways for therapeutic targeting.

#Vasculitis22
Read 5 tweets
Parallel Session III: Proteomics and Metabolomics

RNA Sequencing of Leukocytes Reveals Unique Differences Among Groups of Adult Patients with IgA Vasculitis

Mr. Matija Bajzelj

#Vasculitis22
IgA vasculitis: an introduction

Biopsy gold standard for diagnosis.

#vasculitis22
Methods

Included treatment naive IgA vasculitis

Leukocytes: mRNA isolated

Sequenced on Illumina.

#Vasculitis22
Read 6 tweets
Parallel Session III: Proteomics and Metabolomics

Biomarker and Clinical Data Linkage to Determine the Minimal mRNA Set for Vasculitis Diagnosis

Ms. Gisela Pattarone

#Vasculitis22
Aim was to discriminate healthy volunteers with active vasculitis, active versus remission and future flares using BIOPRED targeted mRNA.

#Vasculitis22
Used next generation sequencing to check a circulating immune profile of the study participants.

#Vasculitis22
Read 5 tweets
Parallel Session I: Epidemiology

Context and Future

Prof Neil Basu

#Vasculitis22
How can epidemiology be applied in vasculitis?

#Vasculitis22
What do we know about the geographical variation in AAV?

Great work done, more to do.

nature.com/articles/s4158…

#Vasculitis22
Read 9 tweets
Parallel Session I: Epidemiology

Characterisation of Systemic Vasculitis Outcomes Across a Nation: Do Different Models of Care Matter?

Dr. Rosemary Hollick

@RJ_Hollick

#Vasculitis22
How can we configure services to better serve patients with vasculitis?

This is the VOICES study.

abdn.ac.uk/iahs/research/…

#Vasculitis22
On to the methods.

Matched cohort study.

GCA or AAV.

1996 - 2020.

#Vasculitis22
Read 7 tweets
Parallel Session I: Epidemiology

Post-Induction ANCA Titer Does Not Predict Relapse, Mortality, or Renal Outcomes: A Target Trial Emulation Study

Dr. Zachary Wallace

@zach_wallace_md

#Vasculitis22
What is AAV?

What about ANCA titres?

Biomarkers key in AAV

#Vasculitis22
Retrospective cohort study

PR3 or MPO AAV

3 outcomes of interest - death, ESKD or relapse

#Vasculitis22
Read 6 tweets
Parallel Session II: Translational Vasculitis

Clinical features and treatment of patients with severe skin changes in IgA vasculitis: multicenter study

Pediatric Rheumatology European Society: Vasculitis Working Group

Dr Marija Jelusic

#Vasculitis22
Aim:
- evaluate prevalence of severe skin manifestations
- propose treatment
- describe clinical course, laboratory findings, and outcome

#Vasculitis22
Methods:
- Observational retrospective multicenter study
- Medical records were used
- Pediatric patients with severe IgA (bullae, ulceration, & necrotic lesion)
- Control group with IgA but no severe skin manifestation

#Vasculitis22
Read 7 tweets
Parallel Session I: Epidemiology

Age and Time-Dependent Increase i Incident Anti-Glomerular Basement Membrane (Anti-GBM) Disease – A Nationwide Cohort Study

Dr. Karl Nelveg-Kristensen

#Vasculitis22
What do we know about anti GBM disease?

#Vasculitis22
Retrospective cohort study

Anti-GBM identified by ICD10 code.

Denmark

#Vasculitis22
Read 8 tweets
Parallel Session II: Translational Vasculitis

Neutrophil mediated T-cell suppression in ANCA vasculitis and Covid-19

Dr Aisling Ui Mhaonaigh

#Vasculitis22
1-slide methods

#Vasculitis22
Main results shown nicely in these graphs

#Vasculitis22
Read 4 tweets
Parallel Session I: Epidemiology

FAIRVASC: A Semantic Web Approach to Rare Disease Registry Integration

Dr. Kris Mcglinn

#Vasculitis22
What are the challenges with rare disease data?

How can these be overcome?

#Vasculitis22
What is FAIRVASC?

#Vasculitis22
Read 7 tweets
Parallel Session II: Translational Vasculitis

Pneumocystis jirovecii pneumonia (PJP) among incident cases of giant cell arteritis and polymyalgia rheumatica

Dr Michael Putman

#Vasculitis22
PJP is a common pathogen in immunocompromised patients but how does this affect patients with GCA or PMR who receive glucocorticoids?

1-slide methods

#Vasculitis22
Baseline cohort characteristics from database

#Vasculitis22
Read 5 tweets
Parallel Session I: Epidemiology

Negative Versus Positive Antineutrophil Cytoplasmic Antibody Granulomatosis with Polyangiitis: A Case-Control Study

Ms Marta Casal Moura

@martacasalmoura

#Vasculitis22
AAV represents a disease spectrum.

#Vasculitis22
How do ANCA negative and positive GPA patients differ?

#Vasculitis22
Read 8 tweets
Parallel Session II: Translational Vasculitis

Anti-complement C5a receptor antibodies are decreased in ANCA-associated vasculitis and associated with relapse

Dr Sebastian Klapa

#Vasculitis22
1-slide methods

#Vasculitis22
Main findings

#Vasculitis22
Read 4 tweets
Parallel Session I: Epidemiology
Air Pollution Risk Factors For Disease Onset Appear Shared Across Systemic Vasculitis and Other Autoimmune Diseases

Mr. Enock Havyarimana

@EnockBugaye

#Vasculitis22
What is particulate matter and how does it impact human health?

#Vasculitis22
Harnessing data from UK Biobank to understand relationship between systemic vasculitis and air pollution.

#Vasculitis22
Read 9 tweets
Parallel Session II: Translational Vasculitis
Baseline soluble immune checkpoints predict relapse risk in PR3-ANCA vasculitis following rituximab induction therapy

Dr Andreas Kronbichler

@AKronbichler

#Vasculitis22
An important question for all patients with AAV is can we predict relapse?

As we don't have many available biomarkers to help with this

Thus, could checkpoints be used?

Knowing that they can cause vasculitis themselves.

#Vasculitis22
Findings for remission, sustained remission, and prediction of relapse

#Vasculitis22
Read 5 tweets

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