Discover and read the best of Twitter Threads about #duplication

Most recents (4)

Finally, the #GoldacreReview is published! (During Parliamentary Easter holidays, mid-ping-pong on the #HealthAndCareBill...)

It's 221 pages - each PDF page is a double page spread - so this could be a lo-o-o-ong [Thread].

Here goes...
First point to note, in the Terms of Reference (p5), is that this is about "access to #NHSdata by #researchers, #commissioners, and #innovators" - i.e. #Planning and #CommercialReUse - so it is directly relevant to the operation of millions of people's #NationalDataOptOuts... Terms of reference for the review  1. How do we facilitate a
"185 wide-ranging recommendations for us to explore", says @sajidjavid (p6). Gulp! Time for some coffee...

"systems that ensure #underrepresented groups are well represented" may (partly) refer to this "landmark review", which got off to a slow start:

gov.uk/government/new… The far-reaching independent review into potential ethnic bi
Read 159 tweets
(1/7) A quality control tool for raw #sequence data. Using #FastQC you may check:
🚀 Per base sequence #quality (do you see a drop in sequencing quality near the read end?). This view shows an overview of the range of quality across all bases at each position in the FASTQ file. Per base sequence quality FastQC
(2/7) Per sequence quality scores (how many reads are the best?) The per sequence quality score report shows whether a subset of sequences has universally low-quality values. Per sequence quality scores FastQC
(3/7) Per base sequence content (the proportion of each base position in a file for which each of the four normal #DNA bases has been called). Ideally, in a random library, we would see four parallel lines representing the relative base composition. Per base sequence content FastQC
Read 7 tweets
1) New tools as #DataMining could help, but!
2) We need #quality not #quantity
3) A lot of papers are useless
4) And other more are unknown to the scientific groups
➡️We have a lot of work to do.
There are more. Thx to @EBaladia for share this: Waste in COVID-19 research by @PaulGlasziou/@bmj_latest bmj.com/content/369/bm…
❌A lot of trials How about quality?
❌Preprints A huge situation
❌Duplication Big problem
@nutriologaedna @MagdaRamrez8 @EvidNutrition @UrsuliuxMed
Read 4 tweets
First completed systematic review on antimalarials (#hydrochloroquine #chloroquine) for #Covid_19
It is a rigorous SR conducted rapidly, NOT a rapid review (less rigour)
Submitted today to journal but preliminary report here to avoid delay in decision-making (1/4🧵)
For others to replicate, we share search strategy and downloadable files
Published and ongoing studies continuously updated here:
app.iloveevidence.com/loves/5e6fdb96…
Let's advocate for #replication not #duplication (waste) in evidence synthesis.
Also, collaboration more than welcome (2/4🧵)
It includes first RCT with reported data.
It has negative findings. Portrays different picture than questionable study hitting the news days ago (Gautret et al)
Thanks to @ConfucioUST for translation (Chinese to English). We are exploring copyright issues before sharing
(3/4🧵)
Read 4 tweets

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