Discover and read the best of Twitter Threads about #isotretinoin
Most recents (4)
We’ve busted some common #isotretinoin myths, but what about actual side effects of isotretinoin in the treatment of #acne. In this Tweetorial, we’ll review the most common side effects and how they can be managed. #dermtwitter #MedEd 1/16
The most commonly reported side-effect is mucocutaneous dryness. It is dose dependent, occurring in 75% of those treated with 0.25-0.5mg/kg/day and in nearly 100% treated with 1mg/kg/day. 2/16
europepmc.org/article/med/21…
europepmc.org/article/med/21…
This can manifest as dry lips, dry skin, and dry eyes. Frequent emollient use (e.g. Vaseline for the lips) can help manage this common side-effect. In addition, a small RCT found 1g/day omega-3 reduced mucocutaneous dryness. 3/16
ncbi.nlm.nih.gov/pmc/articles/P…
ncbi.nlm.nih.gov/pmc/articles/P…
What is the optimal approach to monitoring patients being treated with #isotretinoin for #acne? In this Tweetorial, let’s review the evidence for best practices! #dermtwitter #MedEd 1/13
First, why do we monitor labs?
Benefits:
-Prevent severe adverse effects
-Guide dosing
Downsides:
-Pain
-Fear
-Cost
2/13
Benefits:
-Prevent severe adverse effects
-Guide dosing
Downsides:
-Pain
-Fear
-Cost
2/13
With respect to current practices, as of 2016, over 40% of clinicians were checking CBCs, LFTs, and lipid panels monthly! And rates of monitoring do not appear to be decreasing over time. Is this optimal? 3/13
ncbi.nlm.nih.gov/pmc/articles/P…
ncbi.nlm.nih.gov/pmc/articles/P…
Isotretinoin can be a highly effective treatment for #acne and is the only acne treatment that can provide a lasting remission. However, there are many misconceptions about #isotretinoin. In this Tweetorial, let's bust some common isotretinoin myths! #dermtwitter 1/13
Myth #1 - Isotretinoin and depression: Multiple meta-analyses have found that there is no population level association between isotretinoin use and depression. In fact, isotretinoin may be associated with decreased depressive symptoms. 2/13
jaad.org/article/S0190-…
jaad.org/article/S0190-…
In addition, patients being treated with isotretinoin can expect an average of >50% improvement in quality of life by month 2 and a 4-fold to 5-fold improvement from baseline with a full course of isotretinoin. 3/13
jamanetwork.com/journals/jamad…
jamanetwork.com/journals/jamad…
Just out in @JAADjournals, interesting cohort study led by @ArielleNaglerMD evaluating whether there is an increased risk of suicidality among #acne patients treated with #isotretinoin. A quick thread 1/7
#dermtwitter #dermatology
pubmed.ncbi.nlm.nih.gov/33727021/
#dermtwitter #dermatology
pubmed.ncbi.nlm.nih.gov/33727021/
The authors conducted a cohort study evaluating the rate of psychiatric disorders and suicidality among 3 cohorts: those with acne treated with isotretinoin, those treated with antibiotics only, and those in the general population. 2/7
After adjusting for age and sex, they found that those treated with isotretinoin had increased odds of a psychiatric disorder (e.g. depression) but decreased odds of suicidality compared to those treated with antibiotics and those in the general population. 3/7
