Discover and read the best of Twitter Threads about #kinins

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THREAD from the new #bradykinin research (pre-print) from 🇳🇱:

"We propose that the severity of the disease and many deaths are due to a local vascular problem due to activation of B1 receptors on #endothelial cells in the lungs."

#COVID19 #kinins

preprints.org/manuscript/202…
➡️"the B1 receptor on endothelial cells is upregulated by proinflammatory #cytokines

➡️ Without #ACE2 acting as a guardian to inactivate the ligands of B1, the lung environment is prone for local vascular leakage leading to #angioedema"

...

#bradykinin #COVID19
➡️"... and might explain the typical #CTscans and the feeling of people that they drown.

➡️In some pt., this is followed by a clinical worsening of disease around day 9 due to the formation antibodies directed against the spike (S)-antigen of #SARSCoV2 that binds to #ACE2"
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