Discover and read the best of Twitter Threads about #synuclein
Most recents (1)
Cognitive heterogeneity in Parkinson’s disease: A mechanistic view cell.com/neuron/fulltex…
Our thoughts on #synuclein strains, #Alzheimer pathology, and individual genetic and biomarker characteristics in why individuals with #Parkinson disease manifest so differently. 1/n
Our thoughts on #synuclein strains, #Alzheimer pathology, and individual genetic and biomarker characteristics in why individuals with #Parkinson disease manifest so differently. 1/n
We review how cognition looks in #Parkinsons (short answer: lots of different ways in different people). We review treatment options for cognitive impairment in PD (short answer: not many). We argue that mechanistic focus is needed for better treatment options to emerge. 2/n
Mechanistically, we focus on cell-to-cell spread of pathological #synuclein (aSyn). We think evidence for aSyn spreading and for strains (conformations) of aSyn w different biological behaviors and subsequent cognitive consequences in aSyn diseases is strong. 3/n
