Discover and read the best of Twitter Threads about #cardiorenal

Most recents (22)

๐Ÿ“Œ#Cardiorenal Syndrome
Pathophysiology as a key to the therapeutic approach

#CardioTwitter #CardioEd #NephroTwitter #Review
Management & therapeutic approach๐Ÿ“
Read 3 tweets
1a) Welcome to one of our favorite events on the @academiccme #accredited #tweetorial feeds: a takeover of our programming from @GoggleDocs! The focus of this tweetorial is data from #ADA2022 on #SGLT2i beyond cardiac disease. Our expert author is @GoggleDocs' @drpatrickholmes. Image
1b) Check out our other #ADA2022 recap #tweetorial by new @GoggleDocs family member @Ines_VFonseca who focused on the cardiac data presented: ckd-ce.com/dkd13_ada22a/
2) This program is #accredited for CE/#CME #physicians #physicianassociates #nurses #pharmacists #nursepractitioners & is supported by an educational grant from the Boehringer Ingelheim Pharmaceuticals Inc and Eli Lilly Company. It is intended for healthcare professionals.
Read 59 tweets
1) Welcome to our new #accredited #tweetorial which is Part 2 of a 2-part "highlights" program on new #SGLT2i & #DKD data presented at @ERAkidney #ERA22. #Physicians #nurses #pharmacists #PAs and #NPs can all earn 0.5h CE/#CME by following this ๐Ÿงต!
2a) @ERAkidney #ERA22 is a primary international scientific symposium for interaction and exchange among basic scientists and clinicians working in #Nephrology. Our expert author is Dr. Clara Garcรญa Carro (@ClaraGCarro) from San Carlos Clinical Hospital (Madrid, Spain).
2b) Be sure to check out the first half of this #ERA22 recap from my colleague @shbermejo, and get MORE ๐Ÿ†“CE/#CME at ckd-ce.com/dkd12_ERA22a/. Join me in following @ckd_ce for the BEST in #cardiorenal education delivered entirely by #tweetorial!
Read 48 tweets
1) Welcome to our new #accredited #tweetorial which is Part 1 of a 2-part "highlights" program on new #SGLT2i & #DKD data presented at @ERAkidney #ERA22. #Physicians #nurses #pharmacists #PAs and #NPs can all earn 0.5h CE/#CME by following this thread!
2) @ERAkidney #ERA22 is a primary international scientific symposium for interaction and exchange among basic scientists and clinicians working in #Nephrology. It was held in May. Our expert author is Dr. Sheila Bermejo (@shbermejo) from @vallhebron in Barcelona, Spain.
3) This program is #accredited for CE/#CME & is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance. It is not intended for US- or UK-based based HCPs. Accreditation statement & faculty disclosures at ckd-ce.com/disclosures/.
Read 43 tweets
1) Welcome to a new #accredited #tweetorial on optimizing the role of the pharmacist in managing cardiometabolic disease! Accredited for 0.50 hr for #physicians #nurses #pharmacists! Expert faculty is Snehal Bhatt PharmD @SnayCardsPharmD of @BIDMChealth. Image
2a) This educational activity is supported by grants from Bayer, Otsuka, & Boehringer Ingelheim Pharmaceuticals Inc. and Eli Lilly Company. See archived programs, all by expert authors, still available for credit at ckd-ce.com.
2b) Accreditation statement and faculty disclosures are at ckd-ce.com/disclosures/. We are your ONLY source for accredited education in CKD and #cardiorenal disease delivered wholly on Twitter. FOLLOW US!
Read 24 tweets
Results of the randomized #ADVOR trial are soon coming your way! It's the largest diuretic trial in acute #heartfailure ever conducted (N=519) and will test acetazolamide on top of loop diuretics. Recruitment is finished and full database lock is anticipated. Find out more (1/9). Image
Appropriate and thorough decongestion is class I recommendation in HFA-ESC guidelines (2/9).
academic.oup.com/eurheartj/artiโ€ฆ
#Cardiotwitter #Cardiology #FOAMed #Cardiorenal #MedEd #MedTwitter #Nephrology #ADVOR #HeartFailure2022 #HFA_ESC Image
Only 15% of AHF included in DOSE trial were decongested after 72 hours of high-dose loop diuretic (LD) therapy (3/9).
nejm.org/doi/full/10.10โ€ฆ Image
Read 9 tweets
1) Welcome to a new #accredited #tweetorial on Cardiorenal Disease in T2D & the Impact of Blocking the MR in Patients w/DKD, another CE/#CME program by one of the @GoggleDocs, this time our friend @AmarPut, Diabetes & Endocrine Consultant in the West Midlands ๐Ÿ‡ฌ๐Ÿ‡ง. #CaReMe #FOAMed Image
2) This program is supported by an educational grant from Bayer & is intended for #healthcare providers. Author disclosures can be found at ckd-ce.com/disclosures/. Prior programs, still available for CE/#CME credit, are at ckd-ce.com. CE/#CME credit ๐Ÿ‡ฌ๐Ÿ‡ง๐Ÿ‡ช๐Ÿ‡บ๐Ÿ‡จ๐Ÿ‡ฆ๐Ÿ‡บ๐Ÿ‡ธ
3) So first โ€“ the โ€˜triple threatโ€™ . . . We know of the link between the ๐Ÿซ€ and the kidneys and the โ€˜#cardiorenalโ€™ syndrome, but what about in the setting of #diabetes?
Read 55 tweets
What to do if the eGFR drops from 50 to 42 ml/min/m2 during decongestive therapy in acute #HeartFailure ?
Short #Tweetorial on worsening renal function (WRF) (1/9).
#Cardiotwitter #Cardiology #FOAMed #Cardiorenal #MedEd #MedTwitter #Nephrology #ADVOR #HeartFailure2022 #HFA_ESC
There is an underappreciated risk of poor outcome in heart failure patients discharged with ongoing congestion and WRF (2/9).
Pivotal paper of @MarcoMetra ahajournals.org/doi/10.1161/ciโ€ฆ
Appropriate and thorough decongestion is class I recommendation in HFA-ESC guidelines so DON'T stop decongestive efforts during WRF (3/9).
academic.oup.com/eurheartj/artiโ€ฆ
Read 9 tweets
Which statement is correct with regards to the use of diuretics in #HeartFailure with congestion?

Short #Tweetorial on how to use diuretics in heart failure (1/9).

#Cardiotwitter #Cardiology #FOAMed #Cardiorenal #MedEd #MedTwitter #Nephrology #ADVOR #HeartFailure2022 #HFA_ESC
Door to โ€˜diureticโ€™ time: earlier administration of loop diuretics is associated with improved outcomes independent of HF severity (2/9).
jacc.org/doi/abs/10.101โ€ฆ
The first dose of the loop diuretic should be 40 mg furosemide (=1 mg bumetanide) in diuretic naรฏve and twice the home dose in patients on loop diuretic (3/9).
Read 9 tweets
1/10. Wat is the most important driver of worsening renal function in #HeartFailure ?

Look at #Tweetorial on central hemodynamic derangements in heart failure

#Cardiotwitter #Cardiology #FOAMed #Cardiorenal #MedEd #MedTwitter #Nephrology #ADVOR
2/10. The kidney is a remarkable vascular organ. Renal blood flow = 1000 ml/min, renal plasma flow = 600 ml/min.
3/10. Elevated central venous pressure affects renal function significantly more than reduced cardiac output in heart failure. jacc.org/doi/10.1016/j.โ€ฆ
Read 10 tweets
1/ Nephrologists & cardiologists might agree on 1 #NephMadness region: #CardioRenal

Matchup 1:
Diuretic resistance mechanisms vs treatment

ajkdblog.org/2022/03/01/nepโ€ฆ

So many diuresis roadblocks, summarized below by @hellokidneyMD

@DrFlashHeart @NishaKidneyDoc @HeartDocSadiya Image
2/

Loop diuretics have an S-shaped dose-response curve

ajkdblog.org/2022/03/01/nepโ€ฆ

#NephMadness #CardioRenal @kidney_boy Image
3/

#CardioRenal Matchup 2:
โ™ฅ๏ธ biomarkers in #CKD vs ๐Ÿฅ” biomarkers in โ™ฅ๏ธ disease

NT-proBNP, BNP, & troponin degradation products are filtered through the glomerulus

ajkdblog.org/2022/03/01/nepโ€ฆ

#NephMadness @DrFlashHeart Image
Read 5 tweets
Tweet: renal sodium avidity in #HeartFailure

Do you ever wonder what is happening in the kidney in Heart Failure patients? Hereโ€™s a short #Tweetorial on renal physiology in HF (1/6).
#Cardiotwitter #Cardiology #FOAMed #Cardiorenal #MedEd #MedTwitter #Nephrology #ADVOR
Glomerulus: renal blood flow โ†“ in HF, but the kidney tries to maintain GFR by afferent arteriolar vasodilation and efferent arteriolar vasoconstriction. This leads to single-nephron hyperfiltration initially preserving total GFR, but further damaging the glomerulus. (2/6)
Proximal tubules: hyperfiltration leads to โ†‘ water and solutes filtered, but โ†“ remaining in the peritubular capillaries. Due to โ†‘ peritubular capillary oncotic pressure + โ†‘ renal lymph flow -> โ†‘ water and Na+ reabsorption in the proximal tubules (3/6)
Read 6 tweets
Mineralocorticoid receptor (MR) has a role in:
๐Ÿ‘‰ BP regulation
๐Ÿ‘‰ Electrolyte Homeostasis

Overactivation of MR leads to:
๐Ÿ‘‰ Inflammation and Fibrosis
๐Ÿ‘‰ Sodium retention

#KidneyWk #Nephpearls #Cardiorenal ImageImage
Finerenone: potent and selective non-steroidal MR antagonist (MRA) that is distinct from steroidal MRAs

#KidneyWk #Nephpearls #Cardiorenal ImageImage
FIDELITY pre-specified pooled analysis
๐Ÿ‘‰ FIDELIO-DKD
๐Ÿ‘‰ FIGARO-DKD
#KidneyWk #Nephpearls #Cardiorenal ImageImageImageImage
Read 4 tweets
Role of chloride in AKI from @ThepHunClub @scoca1 #Nephpearls
๐Ÿ‘‰๐Ÿผ journals.physiology.org/doi/pdf/10.115โ€ฆ ImageImage
In CKD patients, higher serum chloride was associated with a modestly steeper rate of eGFR decline, and may be a useful biomarker to predict CKD progression (ca. 2020) #Nephpearls
๐Ÿ‘‰๐Ÿผ bmcnephrol.biomedcentral.com/track/pdf/10.1โ€ฆ ImageImageImage
Serum chloride is strongly & independently asso. w/ worsened survival in patients w/ chronic heart failure (ca. 2016) from @HotSaltsRock @methodsmanmd @KidneydrChirag
#Nephpearls #Cardiorenal
๐Ÿ‘‰๐Ÿผ ncbi.nlm.nih.gov/pmc/articles/Pโ€ฆ ImageImageImage
Read 7 tweets
Thursday mornings at #iqraakidneyclub: Excellent short lecture by Dr Vinugopal on the use of Peritoneal Dialysis in Heart Failure/Cardiorenal Syndromes
Sharing a few slides below:
@hafeeq_benil @drferoz @ranji72 @JyotishGopinat2
#NephTwitter #cardiorenal
How frequent have you started PD for refractory heart failure or CRS type 2?
Starting with the basics -- the classification (which always confuses me btw)
1 & 2 being primarily cardiac, 3 & 4 being primarily renal

1 & 3 being acute, 2 & 4 being chronic
Read 10 tweets
Empagliflozin in Heart Failure: Diuretic and Cardio-Renal Effects
#VisualAbstract by @drM_sudha and @docanjuyadav
#NephJC #Nephpearls
๐Ÿ‘‰๐Ÿผ nejm.org/doi/pdf/10.105โ€ฆ
๐Ÿ‘‰๐Ÿผ ahajournals.org/doi/pdf/10.116โ€ฆ ImageImageImage
Class effects of SGLT2 inhibitors on #cardiorenal outcomes ca. 2019 from @BioMedCentral @McCulloughBHVH #Nephpearls #NephJC
๐Ÿ‘‰๐Ÿผ cardiab.biomedcentral.com/articles/10.11โ€ฆ ImageImageImageImage
Diabetes and Kidney Disease: SGLT2 Inhibitors by @ChristosArgyrop in the August 2019 issue of @KidneyNews #Nephpearls #NephJC
๐Ÿ‘‰๐Ÿผ asn-online.org/publications/kโ€ฆ ImageImageImageImage
Read 10 tweets
Not all elevations in serum creatinine portend bad outcomesโ€ผ๏ธ
#Nephpearls #NephSAP ImageImage
Permissive AKI in the treatment of heart failure ca. 2019 from @Kidney_Int @scoca1 @KidneydrChirag
#Nephpearls #Cardiorenal
๐Ÿ‘‰๐Ÿผ kidney-international.org/article/S0085-โ€ฆ ImageImage
We do not yet know whether stopping RAAS blockade in stage 4 or 5 CKD improves outcomes ... await @STOPACEi_trial findings
๐Ÿ“Œ One of the controversies raised during #KDIGOBPinCKD ๐Ÿ‡ฌ๐Ÿ‡ง meeting #Nephpearls
๐Ÿ‘‰๐Ÿผ kdigo.org/wp-content/uplโ€ฆ Image
Read 6 tweets
McCULLOUGH: Pathophysiology of #Cardiorenal Syndrome
#37VicenzaCourse ๐Ÿ‡ฎ๐Ÿ‡น #Nephpearls
๐Ÿ‘‰๐Ÿผ omicsonline.org/pdfdownload.phโ€ฆ ImageImage
Changes in AKI biomarker concentration over time after renal injury from @CJASN #Cardiorenal
#37VicenzaCourse ๐Ÿ‡ฎ๐Ÿ‡น #Nephpearls
๐Ÿ‘‰๐Ÿผ cjasn.asnjournals.org/content/clinjaโ€ฆ ImageImage
Conceptual model of Cardiac Surgery Associated AKI (CSA-AKI) #Cardiorenal
#37VicenzaCourse ๐Ÿ‡ฎ๐Ÿ‡น #Nephpearls
๐Ÿ‘‰๐Ÿผ onlinejacc.org/content/accj/6โ€ฆ ImageImage
Read 3 tweets
CREDENCE: Canagliflozin reduces the risk of kidney failure or death due to CV or kidney disease by 30% compared to current standard of care ca. 2019 from @NEJM
#VisualAbstract by @brendonneuen
#NKFClinicals ๐Ÿ‡บ๐Ÿ‡ธ #Nephpearls
๐Ÿ‘‰๐Ÿผ nejm.org/doi/pdf/10.105โ€ฆ ImageImage
CREDENCE: Summary of Key Renal and CV Outcomes from @gbakris
#NKFClinicals ๐Ÿ‡บ๐Ÿ‡ธ #Nephpearls
๐Ÿ‘‰๐Ÿผ nejm.org/doi/pdf/10.105โ€ฆ ImageImage
Whether the increased risk of lower limb amputation in the CANVAS Program was due to differing trial populations or protocols, or to chance remains unclear
#NKFClinicals ๐Ÿ‡บ๐Ÿ‡ธ #Nephpearls
๐Ÿ‘‰๐Ÿผ nejm.org/doi/pdf/10.105โ€ฆ ImageImageImage
Read 11 tweets
SZERLIP: Pathologic sequelae of fluid overload in organ systems #Cardiorenal #NKFClinicals ๐Ÿ‡บ๐Ÿ‡ธ #Nephpearls
๐Ÿ‘‰๐Ÿผ nature.com/articles/nrnepโ€ฆ ImageImage
Relationship between fluid overload and inflammatory biomarkers ca. 2018
#NKFClinicals ๐Ÿ‡บ๐Ÿ‡ธ #Nephpearls
๐Ÿ‘‰๐Ÿผ karger.com/Article/Pdf/48โ€ฆ ImageImage
Endothelial glycocalyx determines vascular permeability ca. 2013 from @NEJM #NKFClinicals ๐Ÿ‡บ๐Ÿ‡ธ #Nephpearls
๐Ÿ‘‰๐Ÿผ nejm.org/doi/pdf/10.105โ€ฆ ImageImage
Read 5 tweets
Defining AKI: From lab results to an organic classification
#KDIGOAKI ๐Ÿ‡ฎ๐Ÿ‡น #Nephpearls Image
A basic science view of AKI biomarkers ca. 2014 from @NDTsocial
#KDIGOAKI ๐Ÿ‡ฎ๐Ÿ‡น #Nephpearls
๐Ÿ‘‰๐Ÿผ ncbi.nlm.nih.gov/pmc/articles/Pโ€ฆ ImageImageImage
Proposed utilization of biomarkers in AKI: The combined use of markers of tissue function and pathology would allow patients to be profiled into one of the four quadrants ca. 2014 from @NatRevNeph #KDIGOAKI ๐Ÿ‡ฎ๐Ÿ‡น #Nephpearls
๐Ÿ‘‰๐Ÿผ nature.com/articles/nrnepโ€ฆ ImageImage
Read 10 tweets
SGLT2 Inhibitors and Cardiorenal Outcomes in the February 2019 issue of @KidneyNews
#ISNWCN ๐Ÿ‡ฆ๐Ÿ‡บ๐Ÿฆ˜ #Nephpearls
๐Ÿ‘‰๐Ÿผ kidneynews.org/kidney-news/isโ€ฆ ImageImageImage
EMPA-REG: Empagliflozin, CV outcomes and mortality in Type 2 Diabetes ca. 2015 from @NEJM
#VisualAbstract by @kidney_boy
#ISNWCN ๐Ÿ‡ฆ๐Ÿ‡บ๐Ÿฆ˜ #Nephpearls
๐Ÿ‘‰๐Ÿผ nejm.org/doi/pdf/10.105โ€ฆ ImageImage
CANVAS: Canagliflozin and CV & Renal events in Type 2 Diabetes ca. 2017 from @NEJM
#VisualAbstract by @kidney_boy
#ISNWCN ๐Ÿ‡ฆ๐Ÿ‡บ๐Ÿฆ˜ #Nephpearls
๐Ÿ‘‰๐Ÿผ nejm.org/doi/pdf/10.105โ€ฆ ImageImage
Read 19 tweets

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