Discover and read the best of Twitter Threads about #iimec15

Most recents (15)

The 12th Biomedical Research into ME Colloquium - possibly the best yet
More interest from researchers than ever - justifying resources used/commitment given to make it work
@YoungEmerg @euromeresearch @EUROMEALL
#mecfs #brmec12 #iimec15 #YEMERG03 #EMERG23 #research #cpd
1/23 Image
@YoungEmerg @euromeresearch @EUROMEALL Thanks to #BRMEC12 delegates from around the world coming together in a friendly atmosphere of 2 days/3 evenings of collaborative and productive discussions.
@YoungEmerg @euromeresearch @EUROMEALL
#mecfs #brmec12 #iimec15 #YEMERG03 #EMERG23 #research #cpd
2/23 Image
@YoungEmerg @euromeresearch @EUROMEALL Thanks especially to speakers and our amazing colloquium session chairs from @euromeresearch and @YoungEmerg
Many known collaborations formed -
@YoungEmerg @euromeresearch @EUROMEALL
#mecfs #brmec12 #iimec15 #YEMERG03 #EMERG23 #research #cpd
3/23 ImageImage
Read 23 tweets
#IIMEC15 Ron Davis
He's wearing all black, because it's the "uniform of #MECFS". @DafoeWhitney doesn't do well with color, so he's used to wearing black
How do you determine the molecular cause of #MECFS & #LongCOVID?

and how do you treat it?
Read 18 tweets
#IIMEC15 Professor Robert Phair

The Itaconate Shunt Hypothesis for ME/CFS
Start with TCA cycle

NAD is reduced to NADH, used to make ATP

Looking at part of pathway not in the textbooks - The itaconate shunt
starts at cis-Aconitate

itaconate is converted to itaconyl-CoA with STK to

Up until 7 years ago, that was the end, then found CLYBL. Lab discovered what it does
Read 19 tweets
#IIMEC15 Kristian Sommerfelt

Funcap - Functional Capacity Questionnaire in #MECFS
How do you access functional capacity?

5857 responses from #MECFS patients (online anonymous, spread via social media)
Questions like "can you X? How often do you Y?" don't work, because it is context dependent. It depends on what else the patient has decided to do, doesn't take consequences into account
Read 5 tweets
#IIMEC15 Dr Jesper Mehlsen

TREATMENTS - Toward uniform treatment
regimen for ME/CFS
Listen to patients about what works and what doesn't work.
There isn't an approved medication for #MECFS

Symptomatic treatment can be applied to improve quality of life
Read 8 tweets
#IIMEC15 Professor Jonas Bergquist

Visits to severely affected Patients
Andrea affected at 22 after mild infection (maybe EBV)

Extreme progression after a few months

Today fully bedbound
17 year old case study they published in 2022

"When a 17-year old girl is diagnosed..."

Girl had diary showing how severe Sx, which they plotted and showed fluctuations over many different time scales.
Read 15 tweets
#IIMEC15 Professor Maureen Hanson

Immune Abnormalities and Viruses in ME
65 million people world-wide have #MECFS, same number have #LongCOVID now

Has occurred in outbreaks, some with polio outbreaks
#MECFS symptoms: fatigue, unrefreshing sleep, orthostatic intolerance, cognitive impairment, sore throat, fever, muscular pain, etc
Read 10 tweets
#IIMEC15 Professor Alain Moreau

Long Covid to ME/CFS Transition
challenges of recognizing the facets of #LongCOVID

It's like trying to solve the Rubik's cube with changing colors
SCOPIMED study of #LongCovid

Study population minimum 6 months post Covid, but average 9 months

He mentioned funding from @patientled
Read 13 tweets
#IIMEC15 Professor Karl Johan Tronstad

Metabolic profiling and associations to clinical
data in ME
Gets samples from the clinic (Haukeland University Hospitals) from RituxME and CycloME clinical trials

Did metabolomics on the samples
Energy metabolism

main energy pathway under aerobic conditions
glucose ->pyruvate->Acetyl-CoA goes into Kreb cycle

(dependent on presence of oxygen)
Read 14 tweets
Prof Karl J Tronstad - energy metabolism and associations to clinical data in ME
There is no unified hypothesis that everyone agrees on, but there are observations that are guiding research
Mechanism, treatments and biomarkers of #MECFS - investigating abnormalities in the clinic, biobank and lab
Read 20 tweets
#IIMEC15 Dr Dag Storla

Treatments in a Clinic for Severely Affected
ME/CFS Patients
Staff consists of: registered nurses, research nurse, health care providers, occupational therapist, etc

biomedical approach based on NICE guidelines

Core values: deep respect for patient and individualized care
SF36 fatigue scale and Fitbit HR, HRV, sleep, steps, etc. used for monitoring

4 step program - selected vitamins, minerals, drugs
Read 11 tweets
#IIMEC15 Dr David Systrom

ME/CFS and Long COVID: Insights from Invasive
Cardiopulmonary Exercise Testing
Invasive CPET - exertional intolerance cause elucidated well by this test

mouthpiece measuring gases

catheters - right internal jugular (important part of the test), left wrist to look at blood pressures, measure lactate & other biomarkers
look at VO2 max, patients with ME and LC mildly impaired 70% of expected. If you stop there, might think you have simple deconditioning, but use of catheters show it's not.

Can rule out pulmonary mechanical limit to exercise. Don't see in ME or LC, unless the LC has been on… twitter.com/i/web/status/1…
Read 16 tweets
#IIMEC15 Dr Bhupesh Prusty @BhupeshPrusty

Herpesvirus reactivation as a trigger for
mitochondrial dysfunction in ME/CFS
Hypothesis: acute vs chronic contributors to #MECFS

Normally look into peripheral circulation, but it's connected with tissue

some patients have MCAS, connective tissue issues, microclots
think disease starts in brain, astrocytes, glial cells, muscle cells

Unifying hypothesis - post viral illness, viral reactivation

when we look peripherally, don't find it
Read 24 tweets
First up at #IIMEC15: Professor Simon Carding

Research into ME/CFS in Norwich Research Park twitter.com/i/web/status/1… Image
#MECFS is a multifactorial and complex disease - immune dysregulation, mitochondrial impairment, intestinal dysbiosis, viral infection, neuro-endocrine impairment.
Does #MECFS start in the gut? Microbiome - bacteria, viruses, fungi

Affects immune system fitness (keeps immune system functional), communications of gut-brain axis, influence mood, behavior, linked to greater than 90% of human diseases
Read 19 tweets
Professor Simon Carding, #IIMEC15 conference chair opening the conference: Let's do this for #MECFS & #LongCovid
The latest ground breaking research into #MECFS research. Mission to uncover disease mechanisms for evidence intervention: viruses, autoimmunity, immune senescence; in addition: photobiomodulation, microbiota replacement therapy
A unique cluster of research institutions located within 1 KM
Read 17 tweets

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