Discover and read the best of Twitter Threads about #borrelia

Most recents (18)

NEW RESEARCH: Herbal and enzyme formula effective at reducing #Biofilms. Biofilms are a polysaccharide matrix secreted by microbes to create a protective community. Think of a biofilm like Jello surrounding a raspberry in a dessert (continued in comments). #Lymedisease #Lyme
1/5 Biofilms can make bacteria up to a thousand times more resistant to antibiotics. #Candida and #Borrelia (the bacteria that cause Lyme disease) commonly produce biofilms.
2/5 This newly published research study examined the effect of an herbal and enzyme formula containing NAC, cranberry, berberine, rosemary, peppermint, and enzymes on biofilm mass on five pathogens.
Read 6 tweets
🧵A collection of my favorite research papers, articles and useful documents on #LongCovid #MECFS and other similar infection associated diseases.

1/n
archive.ph/3ywxg
2/ Large compilation of papers on SARS-CoV-2 reactivation/recurrence and persistence.
3/ #MECFS roadmap made by Hip.

"It is possible to make major improvements in health level with the right ME/CFS treatments."
mecfsroadmap.altervista.org

Mini version:
mecfsroadmap.altervista.org/mini-roadmap.h…
Read 17 tweets
Joseph Burrascano, MD - Diagnostic Tools
#Lyme Clinical Presentation: nonspecific, viral-like symptoms that persist, & new ones appear. Then symptoms more focused on musculoskeletal, peripheral and central nervous systems, heart and skin. Muti-systemic & migratory. #ILADS2022 Image
2/Burrascano: Sorting out the co-infections #NotJustLyme #Bartonella #Babesia #Ehrlichia #Anaplasma #Mycoplasma #ILADS2022 ImageImageImageImage
3/Burrascano: Types of tests
SEROLOGIES are indirect, B-cell based tests:
B-cells create antibodies and serologies measure these antibodies #ILADS2022
Read 19 tweets
Robert Bransfield, MD: Thousands of peer-reviewed journal articles demonstrate the causal association between infections and #mentalillness 400+ peer reviewed scientific articles demonstrate the causal association between tick-borne disease and mental illness. #ILADS2022 #Lyme
2/Bransfield: Up to 40% of patients w/ #Lyme develop peripheral or central nervous system involvement. Psychiatric reactions include: #paranoia #dementia #schizophrenia #bipolar #panicattacks #depression #anorexianervosa, and #ODC #ILADS2022
3/Bransfield: Lyme is over represented in psychiatric patients. #ILADS2022
Read 15 tweets
"The Lyme disease bacteria—Borrelia burgdorferi—is definitely one of the smartest bacteria on the planet.⁠ The spirochete is a spiral shaped organism. And because of its spiral shape, and the fact that it has many tales, called flagella... A pink squiggly bacteria (s...
...this organism knows how to move through the tissues. It can disseminate throughout the body and into your central nervous system.⁠
So we know what syphilis can do to the body—which is a spirochetal infection. And the problem is, Lyme is the great imitator, just like syphilis was.⁠

The most common misdiagnoses that I see in my practice are people who have been diagnosed with chronic fatigue syndrome...⁠
Read 9 tweets
#idboardreview 25 M 1 wk post vacation in california mountain cabin: febrile x3d then felt better for 7d and now having fevers again, chills, myalgia, dyspnea progressed to ARDS. wbc3k, Hb11, plt20k, peripheral smear shown. Dx? vector? reservior? #idmeded #IDTwitter Image
#borrelia #hermsii vector: tick, reservoir: rodents
-In USA: spirochete in bloodstream: agents of tick borne relapsing fever #TBRF including B. hermsii
-Spirochetes: genera Spirochaeta, Treponema, Borrelia, Leptospira
-Other regions Borrelia recurrentis louse-borne relapsing F
Read 6 tweets
#idboardreview 30 M from western 🇺🇸 visited Middle East where symptoms of recurrent fevers >102F, headaches, myalgia, chills started
3 wks ago. Peripheral blood smear shown. Dx? #medEd #idmedEd #IDtwitter Image
Rick borne relapsing fever #TBRF #Borrelia persica inspired by jcm.asm.org/content/58/6/e… @ASMicrobiology pic ref P&P Mandell
median incubation period of 7d (range 2-18d): fever x 3d (range 2-7d), alternating w/ afebrile periods lasting about 7d range 4-14d)
If untreated #TBRF can have up to 30 relapses of febrile illness (most pts w/2 relapses)
whereas louse-borne illness is usually has only 1 relapse
Read 7 tweets
This interesting study found that skeletal #muscle cells of #ME/CFS patients showed a decrease in oxidative phosphorylation (a metabolic pathway used by #mitochondria to generate #energy). In simple terms, that caused the cells to have a dysregulated #metabolism.
2/ Not mentioned in the paper, but important to consider, is that most well-studied #viral + bacterial #pathogens “hijack” the metabolism of the cells they infect in a manner that can result in decreased oxidative phosphorylation (or similar changes in cell energy pathways).
3/ In simples terms, these #pathogens “hijack” cell metabolism to “pull” substrates out of the human mitochondrial energy pathways...and use the substrates (lipids, fatty acids, amino acids) for their own #nutritional and replication purposes!
Read 6 tweets
@sickanddamned @__ice9 @GemzME @Cov19longtail @VirusesImmunity @MBVanElzakker Walker hi - I very much disagree that #Borrelia or #EBV are typically ” long gone” in infected patients who develop chronic symptoms.
@sickanddamned @__ice9 @GemzME @Cov19longtail @VirusesImmunity @MBVanElzakker 2/ There is a large body of literature showing that even if such #organisms cannot be found in blood, they can persist in certain tissues or the central #nervous system where they are very hard to identify clinically
@sickanddamned @__ice9 @GemzME @Cov19longtail @VirusesImmunity @MBVanElzakker 3/ This is particularly obvious w/ EBV which is a #herpesvirus. Herpesviruses almost never “clear” after #infection, and symptom resolution is due to the immune system’s ability to contain the #virus in a non-replicating state
Read 10 tweets
Here it is!

#Inktober2020 day 1 in my #PathogenPortraits series. After years of studying this in cow bums, it had to be #EcoliO157

It causes bloody diarrhoea & if that wasn't bad enough, sometimes kidney failure & death. More info @
nhsinform.scot/illnesses-and-…
#sciart #microbiology Inktober2020 E. coli O157 c...
#Inktober2020 day 2 in my #PathogenPortraits series. 'The Clap' (Neisseria gonorrhoeae) b/c who doesn't 💚 green purulent discharge?

It's sexually transmitted but also from mother->newborn during birth to cause blindness.
More info: microbewiki.kenyon.edu/index.php/Neis…

#sciart #microbiology Image
#Inktober2020 day 3 in my #PathogenPortraits series. The very 💛golden💛 #MRSA.

Minds it's own business on your skin, but if it gets inside, methicillin won't do a thing to stop it.

More info at mrsaactionuk.net/MRSA.html #sciart #microbiology Methicillin resistant staph...
Read 34 tweets
@adamswendya @errinbaccari @danaparish Wow thanks for sharing b/c I had not seen the study! What’s awesome is they didn’t just show that #Borrelia cld infect choroid plexus epithelial cells...they also demonstrated the substantial gene expression changes driven by the #pathogen in infected cells
@adamswendya @errinbaccari @danaparish 2/ That Borrelia downregulated genes related to cell to cell junctions (including tight and adherens junctions)...is a a direct mechanism of action finding on how the organism can cause the BBB to become more permeable
@adamswendya @errinbaccari @danaparish 3/ Can you imagine the “double hit” of already harboring Borrelia in the choroid plexus, and then getting #COVID-19 that can infect the same area? Or some version of that pattern? Each pathogen cld support the potential CNS entry of the other
Read 3 tweets
Cool paper detailing what body sites, cell types, symptoms #COVID-19 has been connected to thus far 👉 But one thing: everyone knows that most persistent #viral (and #bacterial) pathogens are capable of #infecting/driving an equally extensive # of #symptoms, right?
2/ For example, in this interview, Dharam Ablashi (who co-discovered the #virus HHV6) explains how HHV6 has been shown capable of contributing to #cancers, type 1 #diabetes, Hashimoto’s, #MS, HPA-axis dysregulation, ME/CFS, Alzheimer’s, neuroinflammation..microbeminded.com/2020/06/28/int…
3/ ..and that the HHV6 can survive in
#microglia, astrocytes, macrophage, neurons/nerves, #pancreatic islet cells, the lung, gut epithelial cells, the #liver etc etc etc!
Read 6 tweets
Cool new study which found that a range of #pathogens (some capable of long-term persistence in tissue + #blood) upregulate expression of the cell surface protein CD47 in the host cells they infect as an #immune evasion strategy
2/ I fact, upregulation of CD47 is a very smart survival strategy by such pathogens, b/c it interferes w/ the host innate immune response that is normally supposed to identify, target and kill them!
3/ Specifically the team found that upregulation of CD47 by the pathogens under study slowed uptake of dead/#infected cells by the #immune system, including the downstream activity of #antigen presenting cells that are needed to recognize pathogens in the first place
Read 10 tweets
This study found that Epstein Barr #Virus (EBV) IgM antibody seropositive #COVID-19 patients had a 3.09-fold increased risk of fever compared to EBV seronegative patients. Inflammatory markers like C-reactive protein were also higher in the EBV+ patients: researchsquare.com/article/rs-215…
2/ The study is a small, but good example of the how already-acquired persistent #pathogens can influence how a person responds to a new #infection: the existing pathogen(s) might cause additional symptoms or influence how the #immune system can respond to the new infection
3/ For example this study found that persistent Cytomegalovirus (CMV) infection caused ~10% of all T cells in CMV+ individuals to be directed against that virus. Could harboring CMV then change how the adaptive immune system responds to COVID-19?: ncbi.nlm.nih.gov/pmc/articles/P…
Read 10 tweets
@DrShawnL Hey - b/c they have shown that amyloid beta appears to actually be an antimicrobial peptide that - at least in the lab/mice - forms in response to a range of bacterial, viral + fungal pathogens capable of persisting in the CNS, including the herpesviruses: ncbi.nlm.nih.gov/pmc/articles/P…
@DrShawnL 2/ Related studies by team’s like @G_Tetz support their findings. Here Tetz found that, in the lab, Tau formation may be additionally promoted by DNA from bacterial pathogens like Borrelia: nature.com/articles/s4159…
@DrShawnL @G_Tetz 3/ Meanwhile herpesviruses have been identified in human Alzheimer’s autopsied brains + shown capable of driving neuroinflammation (cell.com/neuron/pdfExte…) So has oral pathogen p. gingivalis and the toxic gingipains proteins it produces (advances.sciencemag.org/content/5/1/ea…)
Read 7 tweets
1/1 Team uses range of technologies to study brain, heart, kidney + liver tissue of a patient w/ #Lyme disease who received many antibiotics over 16 yrs 👉 Identify significant pathological changes, including borrelial spirochetal clusters in all organs: mdpi.com/antibiotics/an… ImageImageImageImage
2/2 The aggregates contained a well-established #biofilm marker, alginate, on their surfaces, suggesting they are true biofilm 👉 IHC analysis also showed significant numbers of infiltrating CD3+ T lymphocytes present next to #Borrelia burgdorferi biofilms
3/3 Team concludes 👉 “...we provide several lines of evidence that suggest that B. burgdorferi can persist in the human body, not only in the spirochetal but also in the #antibiotic-resistant biofilm form, even after long-term antibiotic treatment”
Read 4 tweets
This same pattern applies to much of the #microbiome community 👉 It’s hard to challenge the “consensus” that the human brain, CSF + womb are “sterile”...when the #NIH barely funds such topics, and novel results from privately funded studies are repeatedly blocked in peer-review
Example 👉 Robert Moir’s novel finding that #amyloid beta functions a potent antimicrobial peptide strongly suggests that communites of #pathogens persist in the #Alzheimer’s brain☝️But read how often his papers have been blocked in peer review: statnews.com/2018/10/29/alz…
Quote from the article 👉 “The first journal [Moir] submitted his results to, #Science, “looked like they would take it,”....But after what editors told him was “a consultation with our #Alzheimer’s disease experts,” it rejected the paper. So did three other journals.”
Read 9 tweets
Why is the future of chronic #inflammatory disease #polymicrobial (organisms interacting)? 👉 This paper describes how even in #Lyme Neuroborreliosis, different strains of Borrelia often persist in a #biofilm, or community-based form: frontiersin.org/articles/10.33… ImageImageImageImage
The ability of Borrelia to form into #biofilm communities may 👉 “explain the low rate of Borrelia detection in the #blood of infected #patients as well as the ability of the #spirochetes to evade the host immune system and resist the antibiotic therapy”: frontiersin.org/articles/10.33…
Here are two images 👉 On the left, a #Borrelia biofilm as seen under a #microscope☝️On the right, a diagram showing how chronic, persister forms of Borrelia can survive inside a #biofilm: where they are better protected from the host immune response: frontiersin.org/articles/10.33… Image
Read 3 tweets

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