Discover and read the best of Twitter Threads about #L452Q

Most recents (10)

#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):

24.63% BA.2.12.1, <- Spike:L452Q
17.54% BA.2,
14.93% BA.2.9,
12.00% BA.2.12,
11.38% BA.2.10,
9.55% BA.2.3, and
2.35% BA.1.1

Tracker (by State): tinyurl.com/mryj4uu7

#OmicronUpdates 05/01/22
#OmicronVariantUpdates #UnitedStates 05/01/22

Top circulating #sublineages: BA.2.12.1, BA.2*, BA.2.9, BA.2.12, BA.2.10, BA.2.3, and BA.1.1

* includes recently designated BA.2.x.y
Read 5 tweets
BA.2.12.1 is the top circulating lineage in the #UnitedStates

It has significant growth advantage over other circulating lineages in #USA

Cov-spectrum predicts a 47% growth advantage over BA.2* (over last three months)

Get #Boosted and #MaskUp!
Tracking Spike #L452Q mutation over time

Current Hotspot: #USA
Emerging Hotspot: #Canada

Tracker: public.tableau.com/app/profile/ra…
Tracking the rise of Spike L452Q mutation in #Canada

Hotspots: #BritishColumbia, #Alberta

Note: Many BA.2.12 (534 sequences) with Spike L452Q & Spike S704L (should have been designated as BA.2.12.1)
Read 8 tweets
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):

23.39% BA.2.12.1, <- Spike:L452Q
19.16% BA.2,
14.85% BA.2.9,
12.25% BA.2.10,
10.79% BA.2.12,
9.43% BA.2.3 and
2.33% BA.1.1

Tracker (by State): tinyurl.com/mryj4uu7

#OmicronUpdates 04/30/22
#OmicronVariantUpdates #UnitedStates 04/30/22

Top circulating #sublineages: BA.2.12.1, BA.2*, BA.2.9, BA.2.10, BA.2.12, BA.2.3, and BA.1.1

* includes recently designated BA.2.x.y
Sequence count by Division - #UnitedStates 04/30/22

#NewYork, #NorthCarolina, #Arizona, #California and #Connecticut have submitted >125 sequences with sample collection dates between April 15 to April 30, 2022.
Read 8 tweets
#COVID19 #VariantDashboard - #UnitedStates

BA.2.12.1 is the top circulating lineage in the USA

Its not the dominating strain yet by looks like it will get there in 2-3 weeks!

Tracker (by State): tinyurl.com/mryj4uu7

#OmicronUpdates 04/29/22
#COVID19 #VariantDashboard

TOP lineages (15-DAY TRENDS) - #UnitedStates:

23.76% BA.2.12.1, <-S:L452Q
19.22% BA.2,
15.47% BA.2.9,
11.81% BA.2.10,
10.45% BA.2.12,
9.31% BA.2.3 and
2.64% BA.1.1

Tracker (by State): tinyurl.com/mryj4uu7

#OmicronUpdates 04/28/22 Image
*Typo corrected: Its not the dominating strain yet *but* looks like it will get there in 2-3 weeks!
Read 13 tweets
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):
27.06% BA.2,
15.80% BA.2.9,
13.04% BA.2.12.1, <---Spike #L452Q
12.27% BA.2.12,
8.97% BA.2.3,
8.13% BA.1.1, and
8.06% BA.2.10

Tracker (by State): tinyurl.com/mryj4uu7

#OmicronUpdates 04/18/22
#OmicronVariantUpdates #UnitedStates 04/19/22

Top circulating #sublineages: BA.2*, BA.2.9, BA.2.12.1, BA.2.12, BA.2.3, BA.1.1, and BA.2.10

* includes recently designated BA.2.x.y
Sequence count by Division - #UnitedStates 04/19/22

#NewYork, #California, ##Texas, #Illinois, #NewJersey and #Washington have submitted >200 sequences with sample collection dates between April 04 to April 19, 2022.
Read 5 tweets
First sequence of BA.2.12.1, the #BA2 #Subvariant with #Spike #L452Q mutation is uploaded in @gisaid from #Arkasnas

This #Omicron #Sublineage has significant growth advantage over BA.2 and BA.1.1

Please get #Boosted!

Get #tested if you have any #COVID19 symptoms
Read 6 tweets
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):

69.07% BA.2*, <--
26.03% BA.1.1*,
4.18% BA.1* &
0.63% None

*#Omicron

Tracker (by State, by Variant): tinyurl.com/mryj4uu7

Updated 04/04/22 Image
#OmicronVariantUpdates #UnitedStates 04/04/22

BA.2 Sequences with sample collection dates in the last 15 days: 3,503

Hotspots (15-Day trends):

>>#NewYork <<

#Texas, #California, #NewJersey, #Washington, #Florida #Massachusetts, #Illinois Image
#COVID19Updates #DeltaRegion 04/04/2022

Top Circulating Variants (last 15 days) in #Alabama, #Arkansas, #Illinois, #Louisiana, #Mississippi, #Missouri, #Kentucky, #Tennessee

BA.2 is the dominant lineage in the Delta Region

Source: tinyurl.com/mryj4uu76 ImageImageImage
Read 4 tweets
#Impfstoffe, #Booster #Covax & #Kommunikation:

1) #AstraZeneca: #EMA STIKO und #Massenmedien, haben diesen Impfstoff so #kaputt #geredet, dass er ab Juli mehr unter die Leute zu bringen war. Es musste verdammt viel #weggeschmissen worden, statt #kreuzgeimpft (AZ+mRNA)

1/x
Obwohl sich abgezeichnet hat, dass eine #Erstimpfung mit #AstraZeneca und eine zeitlich verzögerte #zweite_Impfung mit einem mRNA Impfstoff, einer 2xmRNA Impfung mindestens gleichwertig ist, wurde dieses #heterologe_Impfschema kaum angewendet, da keine STIKO Empfehlung.

2/x
Die Schutzwirkung durch das #heterologe_Prime_Boost_Schema mit AZ + mRNA / #Kreuzimpfung, ist höher, und hält deutlich länger an als zweimal AZ
Dennoch hat man zweimal AZ mit kurzem Abstand zwischen beiden Dosen an Die verimpft, die überhaupt noch AZ imfwillig.

3/x
Read 24 tweets
BREAKING🔔 The 3rd preprint from G2P-Japan - we elucidated the evolution and virological phenotype of #Lambda variant (aka C.37 lineage). Lambda is resistant to vaccine-induced antiviral immunity. Please retweet 1/3
biorxiv.org/content/10.110…
Mutational anaysis showed that a large deletion in the N-terminal domain of the Lambda spike protein (246-253 residues) is responsible for the resiscence to neutralizing antibodies. 2/3
Moreover, #L452Q mutation in Lambda increases viral infectivity, like the case of #L452R mutation, a characteristic of #Delta. Our data suggest that 1) increasing viral infectivity and 2) evading antiviral immunity are crucial for the efficient spread in the human population 3/3
Read 3 tweets
#拡散希望 当ラボ主宰の新型コロナ研究コンソーシアムG2P-Japanのプレプリント第3弾を、bioRxiv @biorxivpreprint に公開しました。本研究では、「注目すべき変異株 #VOI 」のひとつであり、南米で流行拡大する #ラムダ株 のウイルス学的特徴と進化動態を描出しました。1/5
biorxiv.org/content/10.110…
まず、#ラムダ株 が、ワクチンで誘導された #中和抗体 に強い抵抗性を示すことを明らかにしました。次に、ラムダ株特有の、スパイクタンパク質の大きな欠損変異(246-253欠損変異)が、このラムダ株の中和抗体抵抗性を規定していることを明らかにしました。2/5
分子系統学解析の結果、「246-253欠損変異」を持つ #ラムダ株 は、昨年7月頃に誕生し、その後南米各国で流行拡大したことが示唆されました。さらに、#ラムダ株 特有の #L452Q 変異が、#デルタ株#L452R 変異と同様に、ウイルスの感染力を増強させることを明らかにしました。3/5
Read 6 tweets

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