Discover and read the best of Twitter Threads about #platelets

Most recents (10)

Even #mild #COVID #infection increases risk of #blood #clots and #death

A study in the UK found that mild (non-hospitalized) infections led to a 2.7x higher risk of blood clots and 10.2x higher risk of death compared to controls ( heart.bmj.com/node/174901.fu… ). H/T: @LauraMiers 🧵1/ Chart showing hazard ratio of mortality and various cardiova
The study looked at 17,871 COVID-19 cases in the UK between March 2020 and March 2021. People hospitalized *for* COVID-19 were at even higher risk:
118.0x = All-cause Death
27.6 = Venous Thromboembolism (blood clots)
21.6x = Heart Failure
17.5x = Stroke

2/
14.9x = Atrial Fibrillation (AF)
13.6x = Pericarditis
9.9x = Myocardial Infarction (heart attack)

3/
Read 22 tweets
#Prayagraj व देश में #dengue के बढ़ते केस व #platelets के लिए मचे हाहाकार के कारण मैं ये पोस्ट पुनः लिख रहा हूँ!

घर पर बन सकने वाला ये #Ayurveda #काढ़ा #प्लेट्लेट्स संख्या कम होने से सफलतापूर्वक रोकता है, ऐसा मेरा 12 वर्षों का अनुभव है!

कृपया शेयर कर लोगों की सहायता करें!

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2/n
हर साल ये काढ़ा मैं हज़ारों मरीज़ों को देता रहा हूँ, लेकिन फिर भी असंख्य मरीज़ों को ये काढ़ा मैं नहीं दे पाता हूँ,
इसलिए इस काढ़े को #घर_पर_बनाने_का_तरीक़ा मैं फिर से शेयर कर रहा हूँ, ताकि आप इसे घर पर भी भविष्य की ज़रूरत के लिए बना कर रख सकें!
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STEP_1

1 लीटर काढ़ा बनाने में मात्र लगभग ₹3000/ का खर्च आता है (अगर जड़ी बूटियाँ ठीक मिल जाएँ तो), और इतना काढ़ा #Dengue के 2 रोगियों के लिए पर्याप्त है!

निम्नलिखित सूखी हुयी जड़ी-बूटियों को बराबर मात्रा में लीजिएः

1. अतिविषा
2. द्रोणपुष्पी
3. वासा
4. हरीतकी..
Read 16 tweets
1) Welcome to an #accredited #tweetorial on a unique emerging (in Ph3 now) option for specifically reversing the #antiplatelet effects of #ticagrelor: it's #bentracimab. Expert faculty is antithrombotic agent reversal guru @md_pollack of @UMMCnews, working to create #AHealthierMS
2) This program is intended for #healthcare professionals and is supported by an educational grant from PhaseBio Pharmaceuticals. Faculty disclosures are listed at cardiometabolic-ce.com/disclosures/, and prior programs are available for 🆓CE/#CME credit at cardiometabolic-ce.com.
3) It is an unfortunate fact of life that one cannot prescribe #anticoagulant or #antiplatelet (together, #antithrombotic) therapy without increasing a patient's #bleedingrisk. That is why it should be an individualized risk:benefit decision, ideally . . .
Read 51 tweets
Govt of Canada marketing delivered to my home.

"The #vaccinations are safe."

"Up to and including July 16, 2021, a total of 152 deaths were reported after the administration of a vaccine."

Adverse events of special interest as of July 16 2021: 1,675👇

health-infobase.canada.ca/covid-19/vacci…
#Autoimmune diseases:

Guillain-Barré Syndrome: 48
Thrombocytopenia (low blood platelets): 61

#Cardiovascular system:
Cardiac arrest:20
Cardiac failure: 13
Heart attack: 52
#Myocarditis / #Pericarditis: 211

health-infobase.canada.ca/covid-19/vacci…
Adverse reactions continued.

#Circulatory system:

Deep vein #thrombosis: 134
Pulmonary #embolism: 202
#Thrombosis (blood clot): 126
Thrombosis with thrombocytopenia syndrome (blood clot w/ low #platelets): 67

+++

Acute kidney injury: 19
Liver injury: 9

See all👇
Read 11 tweets
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses. Image
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011 Image
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic. Image
Read 199 tweets
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus. Image
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component. Image
Read 213 tweets
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%. Image
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies. Image
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others Image
Read 236 tweets
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed. Image
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues. Image
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin. Image
Read 235 tweets
Platelets are sufficient to drive inflammasome up regulation and activation in myeloid cells, and are *necessary* for full IL-1 production biorxiv.org/content/10.110…. Another great platelet immunology preprint! @bernardo647 #Immunology #Platelets #Inflammasome
Looking at malaria patients with thrombocytopenia shows decreased circulating IL-1 inversely correlating with platelet, but not total leukocyte, numbers, and depletion during PBMC prep almost eliminated IL-1 (and TNF) production in response to LPS!
This preprint also has very thorough evidence that platelets *do not* express inflammasomes or meaningfully contribute IL-1/18, and an exhaustive list of all the ways that platelets *don’t* stimulate myeloid inflammasome activation. Super solid work!
Read 4 tweets
This preprint has it all - explanation of human genetics, platelets as immunomodulators, a new protein-protein interaction involving a solute carrier, NETs biorxiv.org/content/10.110…. And amazing movies! #Immunology #Biochemistry #Platelets
Microfluidics and imaging show binding of neutrophils (and T cells) to activated aIIb-b3 integrin on platelets - independent of known receptors. SLC44A2 binds, and a human SNP linked to decreased risk of venous thrombosis reduces binding. And binding triggers NETosis!
Check out movie 7 - so clear to see the SLC44A2 dependent adhesion of leukocytes to platelets, and the impact of the polymorphism. I love platelet papers for views like those! Looking forward to more biochemistry on the SLC44A2-integrin interaction, but overall very solid paper.
Read 3 tweets

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