Discover and read the best of Twitter Threads about #Cells

Most recents (19)

Mitochondria are essential to our overall health and well-being. In addition to producing energy, they regulate many critical processes in the body. (1/11) #mitochondria #energy #health
Mitochondria play a key role in the production and regulation of neurotransmitters. They also help produce key hormones like cortisol, estrogen, and testosterone. (2/11) #mitochondria #hormones #neurotransmitters #neurotwitter
Mitochondria are involved in epigenetics, which is the expression of #genes from the nucleus. They send signals to the nucleus that turn genes on or off. (3/11) #epigenetics #genes #mitochondria
Read 11 tweets
Ageing: an inevitable part of life. Right? Perhaps not! Recent research from @Harvardmed (10.1016/j.cell.2022.12.027) suggests that ageing may be reversible. This exciting new research may help us better understand ageing! Thread→
@joanna_kacprzyk #Ageing #Biology #Cells
Ageing is a gradual process which occurs at the cellular level in all living things. In humans, this is marked by physical and mental deterioration. Ageing also increases the risk of nearly all diseases. Though thanks to @davidasinclair, there is hope 👏(1/9).
Research published last month in @CellCellPress looked at the cause and potential solutions to ageing. One primary cause of ageing occurs in DNA, though not in the genes themselves (because that would be far too easy!). The changes actually occur at the epigenetic level (2/9).
Read 12 tweets
1/@GraphiteBio presented preclinical results supporting the use of a single-#cell #RNA #sequencing method to assess #gene correction outcomes in #patients treated with nulabeglogene autogedtemcel (nula-cel) - GPH-101. #BioTech #CRISPR #GeneEditing #Genomics $GRPH #ASH22 GraphiteBio presented precl...
2/GPH101 (nula-cel) is a #CRISPR #Cas9 #GeneEditing autologous #stem #cell-based #therapy in clinical development aimed to treat #SickleCellDisease. GPH101 is designed to directly correct the underlying mutation, thereby decreasing HbS production & restoring HbA expression #ASH22 GPH101 (nula-cel) is a CRIS...
3 $GRPH gene correction platform involves editing hematopoietic #stem cells found in the #bonemarrow that develop into various types of #blood #cells. Since red blood cells lose their genomic DNA during maturation-tracking #GeneEditing in mature cells via sequencing is impossible Graphite bio’s gene correct...
Read 7 tweets
Are you interested in learning about #bioinformatics and working with #genomic data? Here's a detailed #learning path to get you started:
To build a strong foundation in biology, you'll need to learn about:
The #structure and #function of #cells, including the various #organelles and their roles in the cell. This will help you understand how cells work and how they carry out essential functions such as #metabolism and #energy production.
Read 12 tweets
"Best practices for single-cell histone modification analysis" w/ @VallotCeline @jeanphi_vert and @PPrompsy.

We identify how to analyze scCUT&Tag, from matrix construction, QC, #cells, up to dimension reduction.

paper: biorxiv.org/content/10.110…
code: github.com/vallotlab/benc… Image
@VallotCeline @jeanphi_vert @PPrompsy We use multiomics assays to evaluate the quality of the representation in a completely unsupervised fashion, by using the kNN-AUC between the two modalities (see openproblems.bio/benchmarks/mul…)

We further look at the 5 most common histone marks on human PBMC and mouse brain data. Image
@VallotCeline @jeanphi_vert @PPrompsy We show that similarly to scATAC-seq, LSI-based methods such as Signac and ChromSCape tend to outperform their competitors.

We further show that enhancing marks (H3K4me1 and H3K27ac) have extremely high agreement with expression data. Image
Read 7 tweets
How precise are noisy #morphogen gradients in #tissue #patterning?

It turns out that the positional information they convey to #cells in the #neuraltube is much more accurate than previously estimated!

Our new #devbio paper is out in @NatureComms: rdcu.be/cH8Fx Image
A methodological subtlety has previously led to overestimated positional errors of the morphogen gradients in the mouse neural tube. We reanalysed the noisy gradients and found that the positional information they can convey to cells is actually orders of magnitude more precise. Image
Also, morphogen gradients in differently sized tissues must not be pooled and rescaled to their mean length, or else an artificial positional error is added. Image
Read 10 tweets
Beware of blue check (w/ few exceptions). #UHN offers ice cream & music in exchange for those willing to take 1st experimental injection - w/ emphasis on #children, 12 yrs of age & up.

UHN Partners:

1. BlueRock
2. CCRM
3. Technion

#4IR #Biotech #Vaccines #CndPoli #tdot
"BlueRock is using its unique cell+gene platform to direct cellular differentiation & #genetically #engineer #cells to create an entirely new generation of cellular medicines in the areas of neurology, cardiology, & #immunology."

#Biotechnology
#Biotech
#UHN partner #CCRM: "A network of academics, industry & entrepreneurs, CCRM translates scientific discoveries into marketable products." CCRM launched in #Toronto on June 14 2011.

The "free" experimental shots will be manufactured by CCRM partner #Pfizer.
Read 5 tweets
"As damaging as #H5N8 has been to birds, it had never infected people. Until February."

nytimes.com/2021/04/21/sci… #pandemics #risk
1/ "The Russian health authorities also tested about 200 of the people involved in the cleanup of the farm in #Astrakhan, using nasal swabs and later blood tests for antibodies. They reported that for the first time, #H5N8 had jumped to people."
2/ "Seven of the workers appeared to have been infected with the virus, although none of them became ill. Only one of those seven cases, however, was confirmed by genetically sequencing the virus."
Read 12 tweets
How do the hundreds of genetic risk-factors for #Schizophrenia actually lead to disease? New work medrxiv.org/content/10.110… from @manoliskellis illuminates the #SingleCell landscape of #Brains from patients with #Schizophrenia and their healthy counterparts🔬🧠🧵1/10
Combining single-nuclear RNA-Seq @10xGenomics, barcode #ing, and multi-level cell-state decomposition, first author Brad Ruzicka et al. identify 20 cell types in the prefrontal cortex of 24 patients with #Schizophrenia and 24 controls 2/10
While most of these #cells have been described before, what's powerful about the approach is that we can now ask: are there specific cell-types that are increased or decreased in numbers in #Schizophrenia patients compared to healthy individuals (great study design) 3/10
Read 10 tweets
Daily Bookmarks to GAVNet 11/04/2020 greeneracresvaluenetwork.wordpress.com/2020/11/04/dai…
To build back better, we will have to reinvent capitalism | World Economic Forum

weforum.org/agenda/2020/07…

#capitalism
How to understand cells, tissues and organisms as agents with agendas | Aeon Essays

aeon.co/essays/how-to-…

#cells #agents
Read 8 tweets
Daily Bookmarks to GAVNet 09/09/2020 greeneracresvaluenetwork.wordpress.com/2020/09/09/dai…
We need to shift our focus from competencies to agency | by Esko Kilpi | Medium

medium.com/@EskoKilpi/we-…

#agency #competencies
Read 8 tweets
Daily Bookmarks to GAVNet 09/04/2020 greeneracresvaluenetwork.wordpress.com/2020/09/04/dai…
Study blows 'greenhouse theory out of the water'

wnd.com/2017/07/study-…

#ClimateChange #greenhouse
Read 14 tweets
Daily Bookmarks to GAVNet 08/07/2020 greeneracresvaluenetwork.wordpress.com/2020/08/07/dai…
The Pandemic's Biggest Mystery Is Our Own Immune System - The Atlantic

theatlantic.com/health/archive…

#pandemic #system #immune #mystery
In northern China, scientists have found what may be the 2 billion-year-old birthmarks of Earth's first supercontinent

sciencex.com/news/2020-08-n…

#china #geological #earth
Read 10 tweets
#Ayurveda #Herbal #real #Tales
1
Saw 64y old #patient with #jaundice and severe #itching all over #body (called #cholestatic #hepatitis) in OPD. Went to 3 other #hospitals prior, always evaluated for #liver and #bileduct #Cancer. Always cancer tests #Negative. Liverbiopsy👇 Image
2
Biopsy shows severe #bile stagnation (#cholestasis) in liver #cells and bile-ducts with #inflammation and #swelling of livercells (#hepatocyte) - classical picture of cholestatichepatitis. CT of liver normal, #MRCP (to see bile ducts) - normal #livertwitter #pathology
CAUSE👇 Image
3
Patient has #diabetes. Tired of #insulin #diet control. #Ayurvedic #physician advises - stop insulin, start #natural side effect free #treatment. Gives these #CAPSULE . After 6 months on #tablet - liver injury and symptoms start. #nutrition deprived, sugar controlled. #MedEd
Read 6 tweets
#Ayurvedic treatment of fatty #liver – real world evidence: A #Thread
1/n
Overweight woman, early 40’s. Routine liver tests, mild enzyme abnormalities. Advised #ultrasound liver, showed grade 2 #fattyliver. GP advised vitaminE and #weightloss, review in 3mo
#livertwitter
2/n
Patient and husband doubtful. Hears fatty liver disease can lead to #cirrhosis. Seeks advice from #Ayurvedic practitioner nearby #home since #Herbal #DRUGS = safe. Assures complete #cure through #Ayurveda. Prescribes multiple #medicines, advises almost all foods restriction.
3/n
Lets look at medicines. #tablet APFIL. Packet mentions ‘for liver #diseases’. Which liver disease? There is #alcohol related, #hepatitis B/C, #NAFLD, primary biliary #cholangitis and more causes. Nine #herbs extract combo - clinical #evidence on safety and benefit ❌
Read 14 tweets
Daily Bookmarks to GAVNet 7/02/2020-2

greeneracresvaluenetwork.wordpress.com/2020/07/02/dai…

Nathaniel Cline and Nathan Tankus: Fiscal Systems, Organizational Capacity, and Crisis: A Political Balance of Payments Approach

nakedcapitalism.com/2013/05/nathan…

#crisis #payments #balance #systems #capitalism #capacity
We might finally know why the coronavirus spread is out of control again

bgr.com/2020/06/30/cor…

#coronavirus #spread
Did protests drive more Covid-19 cases? New research reveals a surprising answer

inverse.com/mind-body/covi…

#COVID19Cases #research #protests
Read 8 tweets
#BlackBirderWeek Day 2 is full of folks doing great #scicom & communication about what the #BlackInNature experience means.

Just a few highlights below!
#TIL during #BlackBirderWeek

1) Paleohistology is a really cool field! Check out @Yara_Haridy 's blog & short clip introducing #fossil remnants of #cells ()
Read 4 tweets

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