Discover and read the best of Twitter Threads about #gene

🧵#Bioinformatics and its impact on #healthcare, a THREAD🧵🧵:

#Bioinformatics is the application of #computational techniques to the analysis of #biological data, such as #DNA sequences and #protein #structures.

In #healthcare, #bioinformatics is used to gain insights into the #genetic basis of diseases, and to develop new #diagnostic tests and #treatments.

Read 11 tweets

Yair Einhorn

@yaireinhorn

1/@GraphiteBio presented preclinical results supporting the use of a single-#cell #RNA #sequencing method to assess #gene correction outcomes in #patients treated with nulabeglogene autogedtemcel (nula-cel) - GPH-101. #BioTech #CRISPR #GeneEditing #Genomics $GRPH #ASH22

2/GPH101 (nula-cel) is a #CRISPR #Cas9 #GeneEditing autologous #stem #cell-based #therapy in clinical development aimed to treat #SickleCellDisease. GPH101 is designed to directly correct the underlying mutation, thereby decreasing HbS production & restoring HbA expression #ASH22

3 $GRPH gene correction platform involves editing hematopoietic #stem cells found in the #bonemarrow that develop into various types of #blood #cells. Since red blood cells lose their genomic DNA during maturation-tracking #GeneEditing in mature cells via sequencing is impossible

Are you interested in learning about #bioinformatics and working with #genomic data? Here's a detailed #learning path to get you started:

To build a strong foundation in biology, you'll need to learn about:

The #structure and #function of #cells, including the various #organelles and their roles in the cell. This will help you understand how cells work and how they carry out essential functions such as #metabolism and #energy production.

Read 12 tweets

🧵#Bioinformatics applied to genomics, a THREAD🧵🧵:

#Genomics is the study of the entire #genetic makeup of an #organism, including its #DNA sequence, #gene structure, and regulation of #gene #expression.

#Bioinformatics is the application of computational techniques, such as #machine #learning and data mining, to the analysis of large datasets of biological information, such as #genomic, #proteomic, and #metabolomic data.

Read 9 tweets

🧬🧵here is a Twitter thread explaining #Bioinformatics in simple terms:🧬🧵

#Bioinformatics is the field that uses computational tools and methods to analyze and interpret #biological #data.

This can include analyzing #DNA and #protein #sequences, predicting the structure and function of #molecules, and modeling biological systems.

Ensembl

@ensembl

1/
It’s another Thursday, and that means it’s time for another #tweetorial! Today, we want to show you how you can view RefSeq #annotations on Ensembl 🥳

#bioinf #genomics #assembly #EnsemblTraining

2/
While Ensembl gene models are annotated directly on the reference genome, #RefSeq are annotated on mRNA sequences. In other words: genome browsers will have different annotation methods, so you might be interested in comparing these annotations side-by-side 📖🤔

3/
👂🏽You say you want to make direct comparisons of annotations between @NCBI’s RefSeq and Ensembl? Now is your time to try it out on Ensembl! 🏃🏽

Read 9 tweets

Antonio Guerrero

@guerreroespejo

Mystery #hepatitis cases in #kids linked to unexpected viral suspect

Two preliminary studies finding #adeno-associated viruses in pediatric hepatitis cases suggest a child's genetic background and other virusesall act in concert
1/
👇
science.org/content/articl…

Researchers found high adeno-associated virus 2 (AAV2) levels in the blood or liver cells in 24 of 25 children with unexplained hepatitis.

In a group of kids without this condition, almost none had AAV2, even those with #adenovirus.
2/

The young #hepatitis patients were also much likelier to have a #genetic variant that may make their immune systems overreact to viruses.
3/

Tom Wiser

@TomWiser

Just a friendly reminder @moderna_tx told the @SECGov that the @US_FDA defines #mRNA as gene therapy. And called it an unprecedented new category of #medicines tho they really want that #vaccine classification anyways for liability protections & fear the public wouldn’t take it.

https://twitter.com/TomWiser/status/1494656849542619138

They know the #COVID19 #vaccine isn’t a vaccine but human #gene #therapy.

The @US_FDA #fda reaffirmed their definition of modified viral #nucleic acid that alters #CELL Jan 30th 2020 #COVID

Read 16 tweets

Ensembl

@ensembl

1/ Knowing the frequency for alleles of genomic variants in populations around the world helps us understand phenotypes and disease 🌎🌍🌏

We’re here to take you through the data in @ensembl step-by-step. A thread…🧵

#genomics #bioinformatics #tweetorial #Ensembltraining🧬

2/ The way you approach this problem will depend on if you are starting with a #gene of interest or if you already have the ID (e.g rs699) of a variant for which you want to find the observed allele frequencies.

3/ If you are starting with a gene, search for the gene name or ID from the #Ensembl homepage and navigate to the Gene tab.

Read 15 tweets

Ensembl

@ensembl

Want to learn about a gene function, but there’s no functional data in your species of interest? Or maybe looking for a homologue of your fav gene in a model organism to carry out functional work? Look no further! This #tweetorial will show you how to find orthologues in @ensembl

2/14
Let’s start on the Ensembl homepage and search for our #gene of interest SCP2 by typing its name into the search box. Then go to the gene tab by clicking on the gene name in the search results.

#Ensembltraining #genomics #bioinformatics #EnsemblCompara

3/14
You can learn more about the #gene function by exploring gene ontology terms and associated phenotypes. Let’s click on Phenotypes in the side menu. This view shows phenotypes associated with our gene of interest and variants in this gene.

Read 14 tweets

Federico Pio Fabrizio

@FPFabrizioPhD

Una terapia genica per aerosol contro la fibrosi cistica? E se fosse la svolta? Vi commento la notizia. Thread spero piacevole ed interessante. 1/n 🧵

Partiamo dalle basi. Il gene #CFTR codifica per una proteina coinvolta nella regolazione degli scambi di ioni tra l’interno e l’esterno della cellula.
2/n

Quando CFTR è colpito da mutazioni, la proteina perde la sua funzione e non riesce a regolare il flusso di elementi fondamentali come il cloro, componente del sudore. 3/n

Read 16 tweets

Federico Pio Fabrizio

@FPFabrizioPhD

Le #cellule #Car-T “peptide-centriche” contro i #tumori solidi: in questo caso ha come #target i #frammenti proteici nelle cellule di #neuroblastoma. Studio di #Nature riassunto in questo thread un po' lungo ma spero interessante. 1/13

Le basi/1. Le terapie CAR-T si basano sull’ingegnerizzazione delle #cellule T (o #linfociti T) del sistema #immunitario del #paziente, che vengono “potenziate” per combattere il #tumore. 2/13

Le basi/2. Per farlo gli scienziati usano un #vettore #virale inattivato contenente un #gene in grado di far esprimere sulla superficie delle cellule T un #recettore chimerico (il recettore dell’antigene chimerico, #CAR, a cui la terapia deve il suo nome). 3/13

Read 13 tweets

Cory Morningstar

@elleprovocateur

"The promise & peril of the Bio Revolution"

"...the world cheered [] that 3 #gene-based COVID19 #vaccines – 1 developed by German #biotech co. BioNTech in collab. w/ Pfizer, another by [] biotech firm Moderna, & a 3rd by [] AstraZeneca – had proved effective in clinical trials."

"But in October, researchers revealed that off-target effects of the #CRISPR-Cas9 #gene-editing tool used to repair a blindness-causing gene in the early stages of human #embryo development often eliminated an entire #chromosome or a large part of it."

#BioengineeringEconomy

"Our deepening knowledge of #biology – #genes, #microbiomes, & neural signals – is making it increasingly possible to "engineer life."... #gene drives applied to infectious-disease vectors [] could save many lives, but we may not be able to control them."

#4IR #Biotech

Read 9 tweets

Cory Morningstar

@elleprovocateur

#COVID19 as catalyst for #4IR #biotech experimentation. The fusion of man & machine sought by the depraved. The foray of #gene editing into public realm. You are the subject.

Jan 24, 2019: "Imperial scientists present #vaccine #revolution to world leaders at #WEF in Davos"

January 2021, TIME, double issue. "The #Vaccine #Revolution" has arrived.

TIME - owned by Marc Benioff, CEO/founder of #Salesforce. World Economic Forum Board of Trustees. Inaugural Chair, Forum Centre for the Fourth Industrial Revolution, San Francisco.

#WEF #4IR #Biotech

#4IR gene-edited, flu-resistant chickens. Working w/ Roslin Inst. Barclay (Imperial) is using #CRISPR technology - to alter the #genome of a species.

April 5, 2020: One of my most thorough, informative & important threads:

https://twitter.com/elleprovocateur/status/1246853634819796997

Read 4 tweets

TheHorizon

@TheHorizonX

Dr Robert Malone - Q: Why do you call the #adenovirus-based (J&J) and #mRNA-based #vaccines #gene therapy-based vaccines? And why is that important? Are you just trying to scare people? Are you an #antivaxxer? linkedin.com/feed/update/ur…

why gene therapy-vaccines? both types of vaccines employ technologies that involve transfering foreign genetic material into the cells of the person receiving the vaccine, making those cells essentially become miniature vaccine antigen manufacturing factories - inside the body👉

for vaccination, the "active drug substance" is not the gene therapy vector, it is the protein that is manufactured in your cells.from an FDA/regulatory point of view, these products need to be reviewed using the regulations applied to "gene therapy" products ... 👉